Topotecan Hrydrochloride
PubChem CID | 60699 |
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Structure |
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Chemical Safety |
Laboratory Chemical Safety Summary (LCSS) Datasheet
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Molecular Formula | C23H24ClN3O5 |
Synonyms |
TOPOTECAN HYDROCHLORIDE 119413-54-6 Topotecan Hcl Hycamtin Topotecan (Hydrochloride) |
Molecular Weight | 457.9 |
Topotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.