Tacrolimus
PubChem CID | 445643 |
---|---|
Structure |
Find Similar Structures
|
Chemical Safety |
Laboratory Chemical Safety Summary (LCSS) Datasheet
|
Molecular Formula | C44H69NO12 |
Synonyms |
tacrolimus Fujimycin Prograf 104987-11-3 Protopic |
Molecular Weight | 804.0 |
Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.