Sulindac
PubChem CID | 1548887 |
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Structure |
Find Similar Structures
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Chemical Safety |
Laboratory Chemical Safety Summary (LCSS) Datasheet
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Molecular Formula | C20H17FO3S |
Synonyms |
sulindac Clinoril 38194-50-2 Arthrocine Sulindaco |
Molecular Weight | 356.4 |
Sulindac is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)