P-CHLORO-M-CRESOL
P-CHLORO-M-CRESOL
USES
For the preservation of adhesives, glues, joint cements, polymer dispersions and emulsions, metalworking/cutting fluids, dyes, industrial lubricants, pigments and filler suspensions, materials in the building industry, paint and coatings, paper, textile, photo, oil industries, and leather at all stages of production.
CHEMICAL AND PHYSICAL DATA
Active ingredient: 99.9% 3-methyl-4-chlorophenol (chlorocresol, p-chloro-m-cresol
Product description: Colorless to white pellets
Chemical name (CA): Phenol, 4-Chloro-3-methyl
SPECIFICATION
The specification parameters can be found in the current product specification.
P-CHLORO-M-CRESOL Preservative is a 98% chlorocresol which is used for the preservation of polymer dispersions and emulsions, metalworking and cutting fluids and industrial lubricants.
p-Chlorocresol (p-chloro-m-cresol; PCMC; brand name: P-CHLORO-M-CRESOL) possesses disinfectant and antiseptic properties.
Chlorocresol is used in various preparations for skin disinfection and wounds.
It also used as a preservative in creams and other preparations for external use which contain water.
For use as a disinfectant such as a hand wash, it is commonly dissolved in alcohol in combination with other phenols.
It is a moderate allergen for sensitive skin.
Chlorocresol produces potentially life-threatening effects which include dermatitis, which are responsible for the discontinuation of chlorocresol therapy.
The symptomatic adverse reactions produced by chlorocresol are more or less tolerable and if they become severe, they can be treated symptomatically, these include hypersensitivity reactions, irritation of eyes.
CHARACTERISTIC DATA
Density: 1.34g/cm3
Bulk Density: 570 to 670 kg/m3
Vapor Pressure (20)°C): <0.0014 Pa
pH (0.4 %): 5.8
Melting Point (°C):63 – 65
Boiling point (1013 HPa):242°C
Flash Point (Closed cup):118°C (244.4°F)
Ignition Temperature: 590°C
pH stability range: ~1-14
SOLUBILITY OF ACTIVE INGREDIENT IN % BY WT.
Ethanol: 500 g/l
10 % NaOH: ~320 g/l
Toluene: ~300 g/l
Water: ~4 g/l
*These items are provided as general information only.
They are approximate values and are not considered to be part of the product specifications.
STORAGE
Product should be stored in the original sealed package. At storage temperature above appropriately 35°C or higher, the product tends to become lumpy.
When exposed to air, light, moisture or heat, the product may turn slightly red.
Change in the color and consistency of product does not affect the efficacy of the product.
The shelf life of P-CHLORO-M-CRESOL Preservative is at least 24 months.
APPLICATION
It is recommended that the P-CHLORO-M-CRESOL Preservative be pre-dissolved (e.g. in alcohol, glycol or caustic soda solution) to ensure the product is evenly distributed in the finished formulation.
P-CHLORO-M-CRESOL Preservative can also be added in the form of an alkaline stock solution.
A stock solution containing 30% P-CHLORO-M-CRESOL Preservative can be formulated by stirring 1 kg P-CHLORO-M-CRESOL Preservative into 1.85 liters of water and 0.5 kg 50 % caustic soda solution until it dissolves.
Dissolving can be accelerated by gently heating the liquid.
The steam-volatility of P-CHLORO-M-CRESOL Preservative must be taken in account in the case of certain applications (e.g. when drying glue slurries which contain P-CHLORO-M-CRESOL Preservative)
MATERIAL PRESERVATION
In the production of dry flues, P-CHLORO-M-CRESOL Preservative should be added toward the end of the thickening stage in order to minimize any losses of the active ingredient.
For polymer dispersion, the P-CHLORO-M-CRESOL Preservative should be added immediately following the polymer dispersion or emulsion stage of the manufacturing process during the cooling process.
For leather applications, P-CHLORO-M-CRESOL Preservative may be dissolved in five times the amount of alcohol and then stirred into pickle solution.
Chrome leather can be preserved by stirring P-CHLORO-M-CRESOL Preservative and caustic soda into basifying solution for optimum incorporation.
P-CHLORO-M-CRESOL Preservative is oil soluble and can be easily dissolved into the fat liquor and added directly to the drum.
For textile applications, P-CHLORO-M-CRESOL Preservative should be incorporated into the dry thickener. Grinding is required.
P-CHLORO-M-CRESOL Preservative could also be added to the ready to use thickener solution.
The EPA approved dosage levels are provided in the chapter “Direction for Use”, but variables such as pH, temperature, initial microbial count or intended storage time of the finished product to be preserved should be taken into consideration.
To obtain reliable and reproducible results, homogeneous distribution in the materials to be protected must be ensured by taking suitable measures in production (stirring, agitating, etc.)
MATERIAL COMPATIBILITY
P-CHLORO-M-CRESOL Preservative is compatible with high quality stainless steel. In the case of plastics, Polyethylene (PE), Polypropylene (PP), Teflon (PTFE) and FRC Atlac 382 are compatible with Preventol Preservative.
Viton and EPDM 75 have shown good compatibility with the P-CHLORO-M-CRESOL Preservative.
As with any product, use of the products mentioned in this publication in a given application must be tested (including field testing, etc.) by the user in advance to determine suitability.
DIRECTIONS FOR USE
It is a violation of Federal law to use this product in a manner inconsistent with its labelling.
The following guidance is given as an approximation for each use pattern, but field-testing is recommended to achieve optimum effectiveness.
Material Preservation
Application
Dosage Level
Adhesives and Glues: 0.05-1.00%
Joint Cements (Not for use in State of CA): 0.075-0.20%
Polymer Dispersion and Emulsions (Not for use in State of CA): 0.05-0.20%
Leather (Not for use in State of CA): 0.05 -0.40%
Lubricoolants and Mineral Oil Based Products:
Concentrates
Ready for Use
1.00-3.00%
0.05-0.30%
Materials in the Printing Industry (Not for use in State of CA):0.05 -0.30%
Materials in the Building Industry: 0.15 – 0.40%
Materials in the Coatings Industry (Not for use in State of CA): 0.05 -0.40%
Materials in the Paper Industry (Not for use in State of CA):0.05-0.30%
Materials in the Textile Industry (Not for use in State of CA):0.05-2.00%
Materials in the Photo Industry (Not for use in State of CA):0.05-0.20%
Materials in the Oil Industry: 0.05 – 2.00%
Additional Materials (Not for use in State of CA)
Polishing and wax material: 0.10-0.40%
Protein solutions
Cleaning solutions, detergents:0.20-0.30%
Ceramic glazes: 0.05-0.20%
Fire extinguishing materials:0.10-0.20%
Materials and auxiliaries in leather industry :0.10-0.30%
Cosmetic and toiletry raw materials :0.10-0.30%
Industrial lubricants: 0.10-1.00%
P-CHLORO-M-CRESOL Preservative is supplied in the form of pellets.
Contact of the product with the skin and the inhalation of dust should be avoided.
The precautions generally recommended for handling chemicals should be observed, e.g. wearing of protective clothing, safety goggles, protective gloves and dust mask.
If the product comes into contact with the skin, the affected area should be washed immediately with large amounts of a polyethylene glycol P 300 and ethanol mixture (2:1) and then with soap and plenty of water; splashes in the eyes should be rinsed out immediately with plenty of water.
If irritation persists, medical attention should be obtained.
Soiled clothing should be changed at once.
The current safety data sheet should be observed.
This contains further information on labelling, transport and storage as well as information on handling, product safety, toxicity and ecology.
CAS-No. 59-50-7
EINECS-No. 200-431-6
IUPAC Name 4-Chloro-3-methylphenol
CAS Name Phenol, 4-Chloro-3-methylCommon name Common name: chlorocresol
EINECS name: Chlorocresol
Trade name: P-CHLORO-M-CRESOL
Synonyms P-CHLORO-M-CRESOL, PCMC, p-chloro-m-cresol
p-chloro-m-cresol (P-CHLORO-M-CRESOL) is an active substance with a specified minimal purity of 99.8%.
The analysis of representative production batches of the active substance were provided.
The relevant impurity m-cresol specification is 0.1%.
Considering the classification of m-cresol and its content in the active substance (0.1%), mcresol is not considered as a substance of concern for (eco)toxicological point of view.
The preparation Dettol new wave is a clear yellow, typically washing-medium odour waterbased liquid formulation (emulsion concentrate), containing 4 % of P-CHLORO-M-CRESOL.
This formulation does not present explosive nor oxidising properties.
It has a self-ignition temperature higher than Chlorocresol Product 100, with a flash point of 36.5°C.
The product is therefore Flam. Liq. 3, H226 according to CLP regulation.
Its density is 0.992 g/l.
The pH of the undiluted formulation is 9.4 while the pH of a 5% dilution is 8.7 at 25°C.
There is no effect of low and high temperature on the stability of the formulation, since after 7 days at 0°C and/or 14 days at 54°C, neither the active ingredient content nor the technical properties were changed.
The surface tension of pure biocidal product is 30 mN/m.
The product is surface active.
After 1 minute, no persistent foam remained, indicating that the preparation is not a foaming product.
Emulsifiability, emulsion stability re-emulsification and Pourability were not measured and must be submitted at product authorization stage.
The content of active substance is unchanged by 3 years storage at ambient temperature but the lack of studies for assessment of technical properties before and after storage prevents RMS to set a shelf life for biocidal product
The intended use of p-chloro-m-cresol (P-CHLORO-M-CRESOL) as PT 1 is:
Main Group 01: Disinfectants, general biocidal products
Product Type 01: Human hygiene.
Further specification: Skin, scalp.
The representative product DETTOL New Wave is a product for hygienic hand disinfection efficacious against bacteria (e.g Escherichia coli).
It is intended for use in hospitals, medical
p-chloro-m-cresol has a multi-site mode of action, with basic activity at the cell wall, disruption of membrane potentials and general membrane permeability of cytoplasmic membrane.
At high concentrations, P-CHLORO-M-CRESOL also has an effect on cytoplasm by general coagulation.practices by professional users (adults only) and for personal hygiene purposes by nonprofessionals.
The basic activity of the substance P-CHLORO-M-CRESOL has been demonstrated for the bactericidal and fungicidal activity, according to phase 1 of efficacy tests, which cannot be used to determine an application rate, relevant for the risk assessment.
The literature analysis clearly showed that especially if the concentration of P-CHLORO-M-CRESOL is in the efficient range (for PT 1: ca. 0.2 % w/w; in-use concentration) no acquired resistance occurs.
In addition, using bactericidal concentrations, the risk of development of cross-resistance or co-resistance is in general low, considering the multi-site activity of P-CHLORO-M-CRESOL.
Since it interacts with many different targets of the bacterial cell wall, the risk of developing resistance mechanisms is minimal.
Few authors described insufficient sporocidal effects of P-CHLORO-M-CRESOL and explained this by development of resistance.
However, P-CHLORO-M-CRESOL is not efficacious against microbial spores and such well-known lack of sporicidal efficacy cannot be interpreted as result of resistance development.
FOR THE PRESERVATION OF ADHESIVES, GLUES, JOINT CEMENTS, POLYMER DISPERSIONS AND EMULSIONS, METALWORKINGiCUTTING FLUIDS, DYES, INDUSTRIAL LUBRICANTS, PIGMENTS AND FILLER SUSPENSIONS, MATERIALS IN THE BUILDING INDUSTRY, PAINT AND COATINGS, PAPER, TEXTILE, PHOTO, OIL INDUSTRIES, AND LEATHER AT ALL STAGES OF PRODUCTION.
P-CHLORO-M-CRESOL Preservative is a high purity chemical suggested as a preservative against bacteria, mold fungi and yeast deterioration for industrial water based compositions, such as adhesives, joint cements, and latex emulsions to impart package stability, leather at all stages of production and metalworking fluids and cutting oils.
The shelf life of the unopened package is a minimum of twelve (12) months.
After opening the package the duration of the effectiveness should be maintained for the useful service life of the product.
Recommended use: The following recommended doses of P-CHLORO-M-CRESOL Preservative must be used to provide preservative efficiency:
ADHESIVES AND GLUES:
Bone glues
Skin glues
Fish glues
Leather glues
Gelatin based glues
Casein containing adhesives
Other animal glues
Starch based glues (liquid)
Starch based glues (solid)
Dextrin·adhesives
Hydroxyethyl cellulose adhesives
Methyl cellulose adhesives
Other plant based adhesives
Polyvinyl acetate adhesives
Polyvinyl alcohol adhesives
Acrylic adhesives
Styrene butadiene (SBR latex) adhesives
Other adhesive emulsions
Gumarabic and similar gums
Rosin paper sizes
EFFECTIVE CONCENTRATION
0.10 – 0.15%
0.15 – 0.25%
0.15 – 0.25%
0.15 – 0.25%
0.10 – 0.20%
0.20 – 0.30%
0.10 – 0.25%
0.10-0.15%
0.20 -1.00%
0.05 – 0.10%
0.05 – 0.10%
0.05 – 0.10%
0.05 – 0.25%
0.05 – 0.25%
0.05 – 0.25%
0.05 – 0.25%
0.05 _ 0.250
0.05 – 0.25%
0.10-0.15%
0.10 – 0.25%
The weight of P-CHLORO-M-CRESOL Preservative to be used is based on the total weight of the adhesive formulation.
The preservative should be incorporated into the adhesive formulation just following the initial addition of water.
The adhesive formulation should be stirred to ensure homogeneous distribution.
In many cases, P-CHLORO-M-CRESOL Preservative is best pre-dissolved in suitable solvent systems such as ethanol or 1,2-propanediol, or by preparation of the preservative in an aqueous caustic soda stock solution to be added to the glues and adhesives to be preserved.
In the production of dry glues, P-CHLORO-M-CRESOL Preservative should be added toward the end of thickening in order to minimize any losses of active SUbstance.
A 30% by weight stock solution of P-CHLORO-M-CRESOL
Preservative is prepared as follows: 1.85 liters of water and 0.5 kg of 50% caustic soda solution are added to 1 kg of P-CHLORO-M-CRESOL Preservative and mixed until homogeneous.
The dissolving process can be accelerated by gentle heating.
Independent of the method chosen, the preservative must be evenly distributed throughout the adhesive or glue to be preserved in order to achieve satisfactory results.
JOINT CEMENTS:
Vinyl latex based
Protein based
Other joint cement materials
EFFECTIVE CONCENTRATION
0.075 – 0.20%
0.075 – 0.20%
0.075 – 0.20%
The weight of P-CHLORO-M-CRESOL·Preservative to be used is based on the total weight of the joint cement formulation.
The preservative should be incorporated into the joint cement formulation just following the initial addition of water or other liquid components sufficient to disperse the preservative.
To ensure homogeneous distribution, good stirring is recommended.
POLYMER DISPERSIONS AND EMULSIONS
Acrylic
Polyvinylacetate (PVA)
Vinyl/Acrylic
Styrene Butadiene (SBR Latex)
Other Polymer emulsions
EFFECTIVE CONCENTRATION
0.05 – 0.20%
0.05 – 0.20%
0.05 – 0.20%
0.05 – 0.20%
0.05 – 0.20%
P-CHLORO-M-CRESOL Preservative should be added immediately after the preparation of the polymer dispersion or emulsion during the cooling process.
Losses of active ingredient caused by elevated temperatures should be taken into account and· avoided by suitable measures.
For quick homogeneous distribution, P-CHLORO-M-CRESOL Preservative should be dissolved in suitable solvents such as ethanol, or 1,2-propanediol, or, alternatively by preparation of water dilutable alkaline solutions.
These pre-dissolved solutions are then added to the polymer dispersions or emulsions.
LEATHER: EFFECTIVE CONCENTRATION
Pickle solutions and pickled hides
Chrome leather (calculated on pelt weight)
Leather pasting adhesives
Leather pigment finishes
0.15-0.25%
0.10 – 0.20%
0.05 – 0.10%
0.20 – 0.40%
P-CHLORO-M-CRESOL Preservative may be dissolved in five times the amount of alcoho: and then stirred into pickle solutions.
In the case of chrome leather, an effective protection’ against attack may be obtained without additional labor by stirring P-CHLORO-M-CRESOL together with soda into the basifying solution, since P-CHLORO-M-CRESOL Preservative dissolves
freely in the alkaline solution.
The oil-soluble P-CHLORO-M-CRESOL Preservative can also be dissolved in the fat liquor andVapplied in the drum simultaneously.
Finished vegetable-tanned leathers and chrome leathers may also be protected against mold attack by a treatment on both sides of the material with an 0.2-0.4% solution of P-CHLORO-M-CRESOL Preservative.
LUBRICOOLANTS AND MINERAL OIL BASED PRODUCTS:
Straight oils (Mineral-oil based)
(concentrates)
(ready for use)
Soluble oils (oil emulsions, aqueous)
(concentrates)
. (ready for use)
Semi-synthetic (emulsions, aqueous)
(concentrates)
(ready for use)
Synthetic (solutions)
(concentrates)
(ready for use)
EFFECTIVE CONCENTRATION
1.00 – 3.00%
0.05 – 0.20%
1.00 – 6.00%
0.05 – 0.30%
1.00 – 6.00%
0.05 – 0.30%
1.00 – 6.00% ‘
0.05 – 0.30%
P-CHLORO-M-CRESOL Preservative can be incorporated into the original concentrate of metalworking fluids by adding the solid preservative under stirring until the preservative is completely dissolved (the compatibility of the fluid to be preserved and the preservative should be evaluated before this method is attempted).
P-CHLORO-M-CRESOL Preservative is equally suitable for tank side addition (maintenance).
In this case, addition of the pre-dissolved preservative mixture is often more favorable.
Suitable solvents for this purpose are, for example, ethanol, or 1,2-propanediol, or, alternatively by preparation of water dilutable alkaline solutions.
To achieve maximum distribution within the ready-to~use dilution of the metalworking fluid, the preservative should be dosed rata point] in the system under conditions which ensure good circulation.
MATERIALS IN THE PRINTING INDUSTRY:
Inks
Fount solutions
Printing pastes
Other printing materials and auxiliaries
EFFECTIVE CONCENTRATION
0.05 – 0.20%
0.05 – 0.20%
0.20 – 0.30%
0.05 – 0.30%
P-CHLORO-M-CRESOL Preservative is incorporated preferably after pre-dissolution. ‘in suitable systems such as ethanol or 1,2-propanediol, or alternatively by preparing water dilutable alkali solutions, which are added to the products to be preserved.
Stirring is recommend to achieve homogeneous distribution of the preservative.
MATERIALS IN THE BUILDING INDUSTRY:
Bitumen emulsions
Concrete additives
Other building materials and auxi.liaries
EFFECTIVE CONCENTRATION
0.15 – 0.40%
0.15 – 0.40% .
0.15-0.40%
P-CHLORO-M-CRESOL Preservative can be added directly to concrete additive solutions having an alkaline pH-value.
The additive solution should be stirred well to dissolve the preservative material efficiently.
In the case of neutral or acid concrete additives, it is preferable to incorporate P-CHLORO-M-CRESOL Preservative first by dissolving it in a suitable solvent such as ethanol or 1,2- propanediol or by converting it to a water dilutable alkaline concentrate.
In this pre-dissolved form P-CHLORO-M-CRESOL Preservative can easily be incorporated into the concrete additives in such a way that preservative is homogeneously distributed throughout the product.
MATERIALS IN THE COATINGS INDUSTRY:
EFFECTIVE CONCENTRATION
Dyestuff paste, knifing fillers and plastic putty
Casein based coatings
Paints
Other auxiliaries and coating materials
Synthetic resin dispersions
0.10-0.15%
0.30 – 0.40%
0.05 – 0.40%
0.05 – 0.40%
0.05 – 0.25%
P-CHLORO-M-CRESOL Preservative can be incorporated directly into pigments and fillers for coatings applications, or it can also be dissolved in a suitable solvent to be incorporated into the make-up water during the grind.
For best results, the preservative should be dispersed homogeneously throughout the paint material.
Depending on the ingredients, discoloration may occur and should be evaluated before conducting lab trials.
MATERIALS IN THE PAPER INDUSTRY:
EFFECTIVE CONCENTRATION
Rosin paper sizes
Filler suspensions and coating compounds
Starch slurries
Pigment slurries
Other materials and auxiliaries
0.05 – 0.15%
0.05 – 0.20%
0.10-0.30%
0.05 – 0.30%
0.05 – 0.20%
P-CHLORO-M-CRESOL Preservative can be metered directly into the products to be preserved following the concentrations as indicated above.
Good stirring is recommended to ensure fast and even distribution of the preservative throughout the products.
In many cases it might be preferable to first pre-dissolve P-CHLORO-M-CRESOL Preservative in suitable solvent systems such as ethanol or 1,2-propanediol, or alternatively by preparation of water dilutable alkaline solutons ,which then are added to the products to be preserved.
Stir well to achieve homogeneous distribution of the preservative.
Losses of active ingredient at elevated temperature taken into account and avoided by suitable measures.
Incorporation of P-CHLORO-M-CRESOL Preservative in dry components of suspensions temperature during grinding does not exceed 60
MATERIALS IN THE
TEXTILE INDUSTRY:
Spinning Preparations
Sizes and finishing agents
Yarn humidifiers
Printing thickeners (solid)
Printing thickeners (liquid)
Other materials and auxiliaries
EFFECTIVE CONCENTRATION
0.05 – 0.15%
0.10-0.15%
0.05 – 0.10%
0.05 – 2.00%
0.10-0.15%
0.05 – 0.20%-
P-CHLORO-M-CRESOL Preservative may be incorporated into the dry thickener by evenly mixing with the preservative to result in a pre-preserVed, dry product.
Alternatively, incorporation of the preservative can be done at the stage of the ready-to-use thickener solution.
In this case, P-CHLORO-M-CRESOL Preservative is best pre-dissolved in suitable solvents such as ethanol or 1,2-propanediol, or an aqueous caustic soda stock solution is prepared and then added to the thickener solutions to be preserved.
For fast and homogeneous distribution of the preservative, stirring is recommended.
MATERIALS IN THE PHOTO INDUSTRY:
Gelatin
Other materials and auxiliaries
EFFECTIVE CONCENTRATION
0.05 – 0.20%
0.05 – 0.20%
Incorporation of P-CHLORO-M-CRESOL Preservative in concentrations as indicated above should be done after pre-dissolving the preservative in suitable solvent systems such as ethanol or 1,2- propanediol or others which are compatible with the individual production process.
MATERIALS IN THE OIL INDUSTRY:
Biopolymers, solid(xanthan, starch, galactomannan, etc.)
Biopolymers, liquid(drilling muds)
Other materials and auxiliaries
EFFECTIVE CONCENTRATION
0.50 – 2.00%
0.05 – 0.20%
0.05 – 0.20%
ADDITIONAL MATERIALS:
Polishing and wax material
Protein solutions
Cleaning solutions, detergents
Ceramic glazes
Fire extinguishing materials
Materials and auxiliaries in the leather industry
Cosmetic and toiletry raw materials
Industrial Lubricants
EFFECTIVE CONCENTRATION
0.10 – 0.40%
0.20 – 0.30%
0.05 – 0.20%
0.10 – 0.20%
0.10 – 0.30%
0.10 – 0.30%
0.10 – 0.30%
0.10-1.00%*
USE BIOCIDES SAFELY.
ALWAYS READ THE LABEL AND PRODUCT INFORMATION BEFORE USE.
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