Macitentan
Summary
Macitentan is an endothelin receptor antagonist used to manage pulmonary arterial hypertension to delay disease progression.
Brand Names: Opsumit
Generic Name: Macitentan
Background
Macitentan was approved in October 2013. It is indicated for patients with pulmonary arterial hypertension, and is marketed under the brand name Opsumit. Macitentan is an antagonist/blocker of endothelin receptors on blood vessels and smooth muscle, and, thus, blocks the stimulation of vasculature hypertrophy, inflammation, fibrosis, proliferation, and vasoconstriction. Similar to all drugs acting on the renin-angiotensin system, macitentan is associated with embryo and fetal toxicity, so it should not be used in pregnancy and has special precautions that must be followed for all females of child-bearing age.
WeightAverage: 588.273
Monoisotopic: 585.963349142
Chemical Formula: C19H20Br2N6O4S