Lurasidone
Lurasidone, sold under the trade name Latuda among others, is an antipsychotic medication used to treat schizophrenia and bipolar disorder.[2] In bipolar it may be used together with a mood stabilizer such as lithium or valproate.[2] It is taken by mouth.[2]
Common side effects include sleepiness, movement disorders, nausea, and diarrhea.[2] Serious side effects may include the potentially permanent movement disorder tardive dyskinesia, as well as neuroleptic malignant syndrome, an increased risk of suicide, angioedema, and high blood sugar levels.[2] In older people with psychosis as a result of dementia, it may increase the risk of dying.[2] Use during pregnancy is of unclear safety.[8][9] How it works is not clear but is believed to involve effects on dopamine and serotonin in the brain.[2]
Lurasidone was approved for medical use in the United States in 2010.[2] In 2019 generic versions were approved in the United States but will not be available until 2023.[10][11] In 2018, it was the 245th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[12][13]