Losartan

Losartan

Summary

Losartan is an angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke.

Background

Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension.³ Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough.³ When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or hydrochlorothiazide.³ Losartan is available as losartan potassium oral tablets as well as a combination tablet of losartan potassium and hydrochlorothiazide.^3,4 Patients taking losartan should have their renal function and potassium levels monitored.³ Losartan was granted FDA approval on 14 April 1995.³

WeightAverage: 422.911
Monoisotopic: 422.162187095

Chemical Formula: C₂₂H₂₃ClN₆O