Lamivudine
| ubChem CID | 60825 |
|---|---|
| Structure |
Find Similar Structures
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| Chemical Safety |
Laboratory Chemical Safety Summary (LCSS) Datasheet
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| Molecular Formula | C8H11N3O3S |
| Synonyms |
lamivudine 134678-17-4 Epivir Zeffix Heptovir |
| Molecular Weight | 229.26 |
Lamivudine is a synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)