Hydroxycarbamide

Hydroxycarbamide

PubChem CID 3657
Structure
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Chemical Safety
Laboratory Chemical Safety Summary (LCSS) Datasheet
Molecular Formula CH4N2O2
Synonyms

hydroxyurea

Hydroxycarbamide

127-07-1

N-Hydroxyurea

Hydrea

Molecular Weight 76.055

Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)

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