Ergotamine and Caffeine Tablet

Ergotamine and Caffeine Tablet

PubChem CID 8223
Structure
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Chemical Safety
Laboratory Chemical Safety Summary (LCSS) Datasheet
Molecular Formula C33H35N5O5
Synonyms

ERGOTAMINE

Ergotamin

Gynergen

Ergostat

113-15-5

Molecular Weight 581.7

Ergotamine is a naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.

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