Ergotamine and Caffeine Tablet
PubChem CID | 8223 |
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Structure |
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Chemical Safety |
Laboratory Chemical Safety Summary (LCSS) Datasheet
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Molecular Formula | C33H35N5O5 |
Synonyms |
ERGOTAMINE Ergotamin Gynergen Ergostat 113-15-5 |
Molecular Weight | 581.7 |
Ergotamine is a naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.