Do lutegravir
Summary
Dolutegravir is an antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents.
WeightAverage: 419.3788
Monoisotopic: 419.129277143
Chemical Formula: C20H19F2N3O5
Background
Dolutegravir is a HIV-1 intergrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI).1 The effect of this drug has no homology in human host cells which gives it an excellent tolerability and minimal toxicity.11 Dolutegravir was developed by ViiV Healthcare and FDA approved on August 12, 2013.15 On November 21, 2017, dolutegravir, in combination with rilpivirine, was approved as part of the first complete treatment regimen with only two drugs for the treatment of adults with HIV-1 named Juluca.16