CALCIUM ACETATE

CAS number: 62-54-4
EC number: 200-540-9
Molecular Formula: Ca(C2H3O2)2
Molar mass: 158.166 g·mol−1
E number: E263 (preservatives)

Calcium acetate is a chemical compound which is a calcium salt of acetic acid.
Calcium acetate has the formula Ca(C2H3O2)2.
Calcium acetates standard name is calcium acetate, while calcium ethanoate is the systematic name.

The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH3COO)2•H2O) is the common form.
Calcium acetate [Ca(CH3COO)2.H2O] is used as a food additive and a mordant to fix dyes in the textile industry.
Calcium acetate is used as an alkali (base) in the manufacture of soaps, to improve some lubricants, and as an antimold to preserve baked goods for a longer shelf life.

Calcium Acetate is a calcium salt of acetic acid.
Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability.
Calcium acetate is administered orally to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties.

Calcium acetate is the calcium salt of acetic acid.
Calcium acetate is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces.
Calcium acetate has a role as a chelator.
Calcium acetate contains an acetate.

What are the uses for calcium acetate?
Calcium acetate is used for reducing blood phosphate levels in people with end-stage kidney disease on dialysis who have high phosphate levels.
Calcium Acetate is available as white powder or agglomerate.
These two versions are chemically identical and differ only in physical form.
The agglomerate offers the properties on non-dustiness, improved wettability, higher reactivity, higher bulk density, and improved free-flow ability.
Calcium Acetate is a moderately water soluble crystalline Calcium source that decomposes to calcium carbonate on heating.

Linear Formula: Ca(C2H3O2)2
MDL Number: MFCD00012448
EC No.: 200-540-9
Beilstein/Reaxys No.: 3692527
Pubchem CID: 6116
IUPAC Name: calcium; diacetate
SMILES: CC(=O)[O-].CC(=O)[O-].[Ca+2]
InchI Identifier: InChI=1S/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
InchI Key: VSGNNIFQASZAOI-UHFFFAOYSA-L

Uses
In kidney disease, blood levels of phosphate may rise (called hyperphosphatemia) leading to bone problems.
Calcium acetate binds phosphate in the diet to lower blood phosphate levels.
Calcium acetate is used as a food additive, as a stabilizer, buffer and sequestrant, mainly in candy products under the number E263.
Tofu is traditionally obtained by coagulating soy milk with calcium sulfate.
Calcium acetate has been found to be a better alternative; being soluble, Calcium acetate requires less skill and a smaller amount.

Because Calcium acetate is inexpensive, calcium acetate was once a common starting material for the synthesis of acetone before the development of the cumene process:
Ca(CH3COO)2 → CaCO3(s) + (CH3)2CO
A saturated solution of calcium acetate in alcohol forms a semisolid, flammable gel that is much like “canned heat” products such as Sterno.
Chemistry teachers often prepare “California Snowballs”, a mixture of calcium acetate solution and ethanol.

The resulting gel is whitish in color, and can be formed to resemble a snowball.
Natural occurrence
Pure Ca acetate is yet unknown among minerals.
Calclacite – calcium acetate chloride pentahydrate – is listed as a known mineral, but its genesis is likely anthropogenic and it may soon be discredited.

Chemical properties
Calcium acetate, also known as acetate of lime or vinegar salts, is the calcium salt of acetic acid.
Calcium acetate is an odorless powder. Calcium has an important role in the nutrition of humans and animals.
Hormonal mechanisms control absorption of dietary calcium (including added calcium salts) allowing adaptation to a range of calcium intakes while maintaining a relatively constant blood calcium concentration of about 10 mg/100 mL.
Major functions of calcium inside the body include the formation and maintenance of bones and teeth, the physiology of muscle contraction, the cell membrane integrity, the activity of several enzymes that have specific requirement for it, the coagulation of blood, and the regulation of acid-base balance.*

Description
Calcium acetate is a chemical compound which is calcium salt of acetic acid.
Calcium acetate has the formula Ca(C2H3O2)2.
Calcium acetates standard name is calcium acetate, while calcium ethanoate is the systematic name.
An older name is acetate of lime.
The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH3COO)2?H2O) is the common form.

Chemical Properties
Calcium acetate occurs as a white or almost white, odorless or almost odorless, hygroscopic powder.

Uses
Calcium Acetate is the calcium salt of acetic acid which functions as a sequestrant and mold control agent.
Calcium acetate contains approximately 25% calcium.
Calcium acetate is a white odorless powder which is readily soluble in water with a solubility of approximately 37 g in 100 g water at 0°c.
Calcium acetates solubility decreases with increasing temperature, with a sol- ubility of approximately 29 g in 100 g of water at 100°c.
Calcium Acetate is the salt of acetic acid which is used as a preservative and sequestrant.

Definition
ChEBI: The calcium salt of acetic acid.
Calcium acetate is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces.

CHEBI:3310
ChEMBL: ChEMBL1200800
ChemSpider: 5890
DrugBank: DB00258
ECHA InfoCard: 100.000.492
EC Number: 269-613-0
E number: E263 (preservatives)

Production Methods
Calcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as lime stone or marble) in vinegar:
CaCO3 + 2CH3COOH → Ca(CH3COO)2 + H2O + CO2
Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then.

The chemical compound calcium acetate is the calcium salt of acetic acid.
Calcium acetate has been commonly referred to as the acetate of lime.
The anhydrous form is very hygroscopic, therefore the monohydrate is the common form.

Physical Description
Anhydrous calcium acetate is a white, hygroscopic, bulky, crystalline solid with a slightly bitter taste.
A slight odour of acetic acid may be present.
The monohydrate may be needles, granules or powder

Uses of Calcium Acetate:
-Antifreezing agents, or de-icing products
-Drug product, or related to the manufacturing of drugs
-Pharmaceutical related
-Related to food production (restaurants, catering, etc)
-Includes antifoaming agents, coagulating agents, dispersion agents, emulsifiers, flotation agents, foaming agents, viscosity adjustors, etc
-Includes spices, extracts, colorings, flavors, etc added to food for human consumption
-Includes food packaging, paper plates, cutlery, small appliances such as roasters, etc.; does not include facilities that manufacture food

Industry Uses
-Functional fluids (open systems)
-Laboratory chemicals
-Lubricants and lubricant additives
-Stabilizing agent, filler
-chemical food additive

Pharmacology
Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia.
The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification.
The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis.
The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus.

Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis.
Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces.
Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders.
Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.

Consumer Uses
-Agricultural products (non-pesticidal)
-Anti-freeze and de-icing products
-Food additive
-Lubricants and greases
-Non-TSCA use

General Manufacturing Information
Industry Processing Sectors
-Agriculture, forestry, fishing and hunting
-Food, beverage, and tobacco product manufacturing
-Petroleum lubricating oil and grease manufacturing
-Pharmaceutical and medicine manufacturing
-Wholesale and retail trade

How should Calcium acetate be used?
Calcium acetate comes as a capsule, tablet, and a solution (liquid) to take by mouth.
Calcium acetate is usually taken along with each meal (e.g., 3 times a day if you eat 3 meals a day) as directed by your doctor. Take calcium acetate at around the same times every day.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take calcium acetate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are using the solution, do not use a household spoon to measure your dose.
Use the dosing cup that comes with the medication to measure your dose.
Ask your pharmacist if you have any question about how much medication you should take or how to use the dosing cup.

Calcium acetate is used to treat hyperphosphatemia (too much phosphate in the blood) in patients with end stage kidney disease who are on dialysis.
Calcium acetate works by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed.
Calcium acetate is available only with your doctor’s prescription.

This product is available in the following dosage forms:
-Solution
-Tablet
-Capsule

WHAT IS CALCIUM ACETATE AND HOW DOES IT WORK?
Calcium acetate is a calcium supplement used to control the level of phosphate in the blood for patients on dialysis due to severe kidney disease.
Calcium acetate is available under the following different brand names: Eliphos, PhosLo, Phoslyra, and Calphron.

Uses
Calcium acetate is used to prevent high blood phosphate levels in patients who are on dialysis due to severe kidney disease.
Dialysis removes some phosphate from your blood, but it is difficult to remove enough to keep your phosphate levels balanced.
Decreasing blood phosphate levels can help keep your bones strong, prevent unsafe buildup of minerals in your body, and possibly decrease the risk of heart disease and strokes that can result from high phosphate levels.
Calcium acetate is a natural mineral that works by holding onto phosphate from the diet so that it can pass out of your body.

How to use Calcium Acetate
If you are taking the over-the-counter product to self-treat, read and follow all directions on the product package before taking this medication.
If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, take it as directed.
This medication is usually taken by mouth with each meal.
The dosage is based on your medical condition and response to treatment.

If you are using the liquid form, use a medication-measuring device or spoon to carefully measure the prescribed dose.
Do not use a household spoon because you may not get the correct dose.
Use this medication regularly in order to get the most benefit from it.
Remember to take it with each meal every day or on the schedule given to you by your doctor.

Precautions
Before taking calcium acetate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Calcium acetate may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details.

Calcium acetate should not be used if you have a certain medical condition. Before using this medicine, consult your doctor or pharmacist if you have: a high blood calcium level (hypercalcemia).
Before using this medication, tell your doctor or pharmacist your medical history.
During pregnancy, this medication should be used only when clearly needed.

Discuss the risks and benefits with your doctor.
Calcium acetate passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
Calcium acetate is a phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism.

Production method
Calcium acetate is obtained by the reaction between calcium carbonate and acetic acid.
Preparation method of anhydrous calcium acetate: the refined powder of calcium carbonate is added to the water, stirred into a suspension; added separately of a small amount of glacial acetic acid.
After completion of the reaction, the filtrate was concentrated in a water bath and a white solid, anhydrous calcium acetate, was precipitated from the viscous filtrate.

Calcium acetate is obtained by the neutralization between coke acid (wood acetic acid) and calcium hydroxide, followed by the evaporation of the filtrate and recrystallization.
Calcium acetate is obtained by the reaction between the reaction between acetic acid and calcium hydroxide or calcium carbonate.
Filter, concentrate and cool to obtain the dihydrate (colorless crystal), heated to 84 °C in a water salt (colorless crystal), heated to 100 °C to obtain the anhydrous salt.

Shellfish can be taken as raw materials, washed, crushed and dried for 1 h, subjecting to barbecue for 2 hour at 900~l000 ℃, then being added water to make a 1.3~1.5mol/L lime milk.
And then neutralized with acetic acid to clarify, filter with the filtrate concentrated, and finally dried at 120~140 °C to get the final product with a yield of 91.28%.
To a 20% acetic acid solution, add calcium carbonate powder to until there is no longer any CO2 gas escaping, then add a small amount of calcium carbonate, heated 80 ° C for reaction of 2-3h.
The filtrate was heated and concentrated with water bath while adding a small amount of 80% acetic acid at the same time to precipitate the calcium acetate monohydrate (what precipitated after the cooling of the solution is dihydrate), and finally dried at 60~70 ℃to derive the products.

What is calcium acetate?
Calcium is a mineral that is needed for many functions of the body, especially bone formation and maintenance. Calcium can also bind to other minerals such as phosphate, and aid in their removal from the body.
Calcium acetate is used to control phosphate levels to keep them from getting too high in people with kidney failure who are on dialysis.
Calcium acetate may also be used for purposes not listed in this medication guide.

What is the most important information I should know about calcium acetate?
You should not use calcium acetate if you have high levels of calcium in your blood.

What is calcium acetate?
Calcium is a mineral that is needed for many functions of the body, especially bone formation and maintenance.
Calcium can also bind to other minerals such as phosphate, and aid in their removal from the body.
Calcium acetate is used to control phosphate levels to keep them from getting too high in people with kidney failure.
Store at room temperature away from moisture and heat.

Production
Calcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as limestone or marble) or hydrated lime in vinegar:
CaCO3(s) + 2CH3COOH(aq) → Ca(CH3COO)2(aq) + H2O(l) + CO2(g)
Ca(OH)2(s) + 2CH3COOH(aq) → Ca(CH3COO)2(aq) + 2H2O(l)
Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then.

Calcium Acetate (Phoslo)
Calcium is a mineral that is needed for many functions of the body, especially bone formation and maintenance. Calcium can also bind to other minerals such as phosphate, and aid in their removal from the body.
Calcium acetate is used to control phosphate levels to keep them from getting too high in people with kidney failure who are on dialysis.
Calcium acetate may also be used for purposes not listed in this medication guide.

Uses of Calcium Acetate:
-Industrial fluids such as hydraulic fluids, lubricating agents, functional fluids, etc
-Generic lubricants, lubricants for engines, brake fluids, oils, etc (does not include personal care lubricants)
-Generally related to automobiles or their manufacture
-Chemicals in cigarettes, or tobacco related products, or related to the manufacturing of tobacco products
-Drug product, or related to the manufacturing of drugs; modified by veterinary, animal, or pet if indicated by source
-Related to manufacturing for export
-Manufacturing of or related to machinery, for production of cement or food, air/spacescraft machinery, electrical machinery, etc

What is this medicine?
CALCIUM ACETATE (KAL see um ASa tate) is a calcium salt.
Calcium acetate works to bind phosphate in the digestive tract.
Calcium acetate is used to treat high levels of phosphate in patients with chronic renal failure.
Calcium acetate may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:

What is calcium acetate, and how does it work (mechanism of action)?
Calcium acetate helps reduce phosphate levels in people with advanced kidney disease.
People with advanced kidney failure retain phosphate leading to too much phosphate in their bodies (hyperphosphatemia).
High phosphate levels cause hyperparathyroidism, which leads to abnormal bone formation and calcium deposits in tissues.
Calcium acetate is a phosphate binder.
Calcium acetate, when taken with meals, combines with phosphate in food to form calcium phosphate, which is poorly absorbed into the body and is excreted in the feces.
Binding phosphate in the intestines reduces absorption of phosphate into the body.

Uses of Calcium Acetate:
-Beverages for human consumption (e.g., juice, water, alcohol), or related to beverages for human consumption (e.g. machinery for production of beverages, or facilities serving beverages)
-Substances used for preventing, destroying or mitigating pests
-Chemical which can deter, destroy, or control a harmful organism by chemical or biological means
-Includes preservatives used in cosmetics, film, wood preserving agents, foods, etc
-Accelerators, activators, oxidation agents, reducing agents, etc
-General stabilizers

Consumer Uses
Calcium acetate is used in the following products: lubricants and greases. Other release to the environment of Calcium acetate is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Article service life
Release to the environment of Calcium acetate can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release.
Other release to the environment of Calcium acetate is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).
Calcium acetate can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and plastic (e.g. food packaging and storage, toys, mobile phones).

Widespread uses by professional workers
Calcium acetate is used in the following products: fertilisers, lubricants and greases, fillers, putties, plasters, modelling clay, textile treatment products and dyes and anti-freeze products.
Calcium acetate is used in the following areas: agriculture, forestry and fishing and building & construction work.
Calcium acetate is used for the manufacture of: chemicals, textile, leather or fur, mineral products (e.g. plasters, cement) and machinery and vehicles.
Other release to the environment of Calcium acetate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Formulation or re-packing
Calcium acetate is used in the following products: lubricants and greases, fertilisers, air care products, paper chemicals and dyes and polymers.
Release to the environment of Calcium acetate can occur from industrial use: formulation of mixtures and formulation in materials.

Uses at industrial sites
Calcium acetate is used in the following products: lubricants and greases, polymers, anti-freeze products, fertilisers, non-metal-surface treatment products, inks and toners and paper chemicals and dyes.
Calcium acetate is used in the following areas: formulation of mixtures and/or re-packaging.
Calcium acetate is used for the manufacture of: chemicals, machinery and vehicles and plastic products.
Release to the environment of Calcium acetate can occur from industrial use: in processing aids at industrial sites and of substances in closed systems with minimal release.

Manufacture
Release to the environment of Calcium acetate can occur from industrial use: manufacturing of the substance.

IUPAC NAMES:
Acetic acid, calcium salt
calcium (di)stearate
Calcium Acetate
Calcium acetate
Calcium acetate
Calcium acetate monohydrate
calcium bis(acetate)
calcium di(acetate
CALCIUM DI(ACETATE)
Calcium di(acetate)
calcium di(acetate)
Calcium di(acetate)
Calcium diacetate
acetatedecalcium
Aceticacid,calciunsalt
teltozan
vinegarsalts
CALCIUM ACETATE EXTRA PURE, FCC, E 263
CALCIUM ACETATE HYDRATE PURE
CALCIUM ACETATE HYDRATE, 99.99%
CALCIUM ACETATE SIGMAULTRA
CALCIUM ACETATE SOLUTION
CALCIUM ACETATE 99.999%
CALCIUM ACETATE HYDRATE, REAGENTPLUS TM >= 99%
CALCIUM ACETATE HYDRATE, POWDER
CalciumAcetateFcc
CalciumAcetateBp
CalciumAcetateDried(ForSoilTest)
FEMA 2228
CALCIUM ACETATE
Calcium acetate – dried
CALCIUM DIACETATE
MAGNESIA 87219
MAGGRAN(R) CA
ACETIC ACID, CALCIUM SALT
CALCIUM ACETATE PWD
brownacetate
brownacetateoflime[qr]
grayacetate
grayacetateoflime[qr]
limeacetate
limepyrolignite
sorbo-calcion
CalciumAcetateGr
CalciumAcetateUsp
CalciumAcetate,>98%
Calcium acetate hydrate, Puratronic, 99.9965% (metals basis)
Calciumacetatemonohydrate,98%
CALCIUMACETATE,POWDER,FCC
CALCIUMACETATE,POWDER,FCC(BULK
CALCIUM(II)ACETATE
Calciumacetat
CALCIUM ACETATE POWDER
Calciumacetatehydrate,97%
CALCIUM ACETATE 1-HYDRATE
Brown acetate of lime
Gray acetate of lime
Di(acetic acid)calcium
Calcium acetate hydrate, Puratronic
Calcium acetate ,99%
Acetic acid, calciuMsalt (2:1)

March 25, 2022

By admin

CALCIUM ACETATE

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