Gamma-hydroxybutyrate
Overview
Gamma hydroxybutyrate (GHB) is a chemical found in the brain and other areas of the body. It can also be made in a laboratory.
GHB used to be available as a dietary supplement in the U.S., but it was taken off the market in 1990 because of safety concerns. It is now a Schedule I controlled substance, making it illegal to produce, sell, or possess. A prescription form of GHB called sodium oxybate (Xyrem) is still available for treating excessive daytime sleepiness (narcolepsy). It is a Schedule III controlled substance, which means that it requires a prescription and close monitoring by a medical doctor.
The prescription form of GHB is used for excessive daytime sleepiness (narcolepsy). It has also been used for alcohol use disorder and opioid withdrawal.