Vismodegib
| PubChem CID | 24776445 |
|---|---|
| Structure |
Find Similar Structures
|
| Molecular Formula | C19H14Cl2N2O3S |
| Synonyms |
Vismodegib 879085-55-9 GDC-0449 Erivedge 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide |
| Molecular Weight | 421.3 |
Vismodegib is an orally bioavailable small molecule with potential antineoplastic activity. Hedgehog antagonist GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO.