Rifampin
Summary
Rifampicin is an antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis.
Brand Names: Isonarif, Rifadin, Rifamate, Rifater, Rofact
Generic Name: Rifampicin
Background
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Weight Average: 822.9402
Monoisotopic: 822.40512334
Chemical Formula: C43H58N4O12