Methohexital
| PubChem CID | 9034 |
|---|---|
| Structure |
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| Chemical Safety |
Laboratory Chemical Safety Summary (LCSS) Datasheet
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| Molecular Formula | C14H18N2O3 |
| Synonyms |
METHOHEXITAL Methohexitone Methodrexitone 151-83-7 Metohexital |
| Molecular Weight | 262.30 |
Methohexital is a rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability, and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses.