Empagliflozin
Dosage Forms & Strengths
tablet
- 10mg
- 25mg
Type 2 Diabetes Mellitus
Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes
Also indicated to reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and cardiovascular disease
10 mg PO qDay
May increase to 25 mg/day if needed and tolerated
Dosage Modifications
Hepatic impairment: No dosage adjustment required
Renal Impairment
- eGFR ≥45 mL/min/1.73 m2: No dosage adjustment required
- eGFR 30-45 mL/min/1.73 m2: Do not initiate therapy; if already on it, discontinue therapy when eGFR persistently <45 mL/min/1.73 m2
- eGFR <30 mL/min/1.73 m2: Contraindicated
Dosing Considerations
Limitation of use: Not indicated for treatment of type 1 diabetes or diabetic ketoacidosis
Assess renal function before initiating and periodically thereafter
In patients with volume depletion, correcting this condition before initiating treatment