POLYSORBATE 20
POLYSORBATE 20
Polysorbate 20 is a polyoxyethylene sorbitol ester that belongs to the polysorbate family. Other names: Montanox 20; Polysorbate 20; PEG(20)sorbitan monolaurate; Alkest TW 20; Tween 20. As a non-ionic surfactant, Polysorbate 20 has a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, one sorbitol, and one lauric acid as the primary fatty acid.
Polyoxyethylene 20 Sorbitane mono-Laurate
Polysorbate 20
Polysorbate 20 is a liquid cleansing agent and solubilizer for use in hair care, toiletries, perfumes and fragrances.
This grade is recommended as an emulsifier for O/W systems and effective solubiliser for essnetial oils and perfumes in aqueous and aqueous/alcoholic systems. It is also used as a mildness additive in detergent systems e.g. baby shampoo and cleansing agent in wet wipes.
Polysorbate 20 is a polyoxyethylene sorbitol ester that belongs to the polysorbate family.
It is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, 1 sorbitol, and 1 lauric acid as the primary fatty acid.
The ethylene oxide subunits are responsible for the hydrophilic nature of the surfactant, while the hydrocarbon chains provide the hydrophobic environment.
Sorbitol forms the backbone ring to which the ethylene oxide polymers are attached.
Polysorbate 20 is miscible in water (100mg/mL), yielding a clear, yellow solution.
It is also miscible with alcohol, dioxane, and ethyl acetate.
Polysorbate 20 is insoluble in liquid paraffin and fixed oils.
IUPAC name: Polyoxyethylene (20) sorbitan monolaurate
Other names: Montanox 20; Polysorbate 20; PEG(20)sorbitan monolaurate; Alkest TW 20; Tween 20
polyethyleneglycol sorbitan monolaurate, Polysorbate 20, Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs; SORBITAN MONOLAURATE POLYETHOXYLATE;Sorbitan monolaurate, ethoxylated;Sorbitan monolaurate, ethoxylated (1-6.5 moles ethoxylated);Sorbitan, mono-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs., (Z)-; Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs.
SORBILENE L/4;Tween 21
SYNONYMS: Tween 20; Polyoxyethylene Sorbitan Monolaurate;POE (20) sorbitan monolaurate; Polysorbate 20;
Polysorbate 20 is fully saturated liquid ester.
Recommended as an emulsifier for O/W systems and as an effective solubilizer for essential oils and perfumes in aqueous and aqueous/alcoholic systems.
Also used as a mildness additive in detergent systems.
Tween 20, or Polysorbate 20, is a popular choice for biochemical applications.
With a hydrophobic dodecanoic tail, it attached to 20 repeat units of polyethylene glycol and distributed across four different chains.
Functions
Counter Irritants
Dispersing Agents
Solubilisers
Emulsifiers
Surfactants / Detergents
Applications
Wet wipes
Bath, Shower & Soaps
Eye Contour Care
Face / Neck Skin Care
Facial Cleansers
Shampoos
Shaving / Hair Removal
Styling
Sun Protection
As a non-ionic surfactant, Polysorbate 20 has a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, one sorbitol, and one lauric acid as the primary fatty acid.
This product can be used as a solubilizing agent in oil-in-water emulsifications as well as a humectant in skin care products.
In addition, polysorbate-20 is frequently used as an indirect additive for food emulsification.
Other names: Polysorbate 20, Polyoxyethylene(20)sorbitan monolaurate,
Poly(oxy-1,2-ethanediyl) derivatives, armotan PML-20, Capmul, Dxemulse POE-SML,
Emsorb6915, Glycosperse L-20, Hodag psml-20, Liposorb L-20, protasorb L-20, Sorbimacrogol Laurate 300
CAS: [9005-64-5]
The ethylene oxide subunits are responsible for the hydrophilic nature of the surfactant, while the hydrocarbon chains provide the hydrophobic environment.
Ethylene oxide polymers attach to the backbone ring, which is formed by sorbitol.
Polysorbate 20 is also miscible in water (100 mg/ml) and yields a clear, yellow solution.
It is practically insoluble in liquid paraffin and fixed oils, and also miscible in alcohol, dioxane, and ethyl acetate.
(1) Polysorbate 20
English name: Polyoxyethylene (20) Sorbitan monolaurate or Polysorbate 20
Code name: Polyoxyethylene sorbitan monolaurate (Tween 20)
Appearance:light yellow to yellow oily liquid
HLB Value: 16.7
CAS number: 9005-64-5
Synonyms
Tween 20: Polysorbate-20 : Polysorbate : polyoxyethylene(20)sorbitan tristearate : Polyoxyethylene(20)sorbitan monostearate : Polyoxyethylene(20)sorbitan monooleate : Polyoxyethylene(20)sorbitan monolaurate
Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products.
It is composed of 20 repeated units of polyethylene glycol via ethoxylation.
Polysorbate 20 is a wetting agent in food products, as well as washing agent, stabilizer and solubilizer in labratory assays and industrial applications.
It is also an excipient that stabilizes emulsions and suspensions in pharmaceutical products and lubricant in ophthalmic solutions.
polisorbato Español
Polysorbate
polysorbate Français
Polysorbate 20 ChemIDplus
polysorbatum LINGUA LATINA
Synonyms
Polyoxyethylene (20) sorbitan monolaurate
Polyoxyethylene sorbitan monolaurate
Tween 20
CAS Number: 9005-64-5
Solubilizer (Polysorbate 20)
Solubilizer (Polysorbate 20) is a water solubiliser for essential oils and perfume compounds.
It has a faint warm-oily shampoo like note. Use from 4 parts Polysorbate 20 to, 1 part oil or compound.
Mix the Polysorbate with the oil or perfume compound well then add the water slowly, stirring all the time.
Note: Using some ethanol (20-30%) with the water will help the clarity of the end product and you may be able to reduce the amount of solubilizer necessary.
As with all solubilisers the exact amount required for a completely clear solution depends on each compounds own ingredients and some materials like citrus oils and resins are almost impossible to get completely clear.
Odour
The odour and uses of Solubilizer (Polysorbate 20)
Odour=> They all have only very faint warm-oily odor or practically no odor while they do have a bitter taste in concentrations exceeding 500 ppm They all have only very faint warm-oily odor or practically noodor while they do have a bitter taste in concentrations exceeding 500 ppm
Perfume-Uses=> Tea, Vegetable, Food-additive, Baked-foods,
Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.
Polysorbate 20
Polyoxyethylene (20) sorbitan monolaurate
CAS: 9005-64-5
An oily liquid derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids.
Other Known Names: PEG(20)sorbitan monolaurate, Alkest TW 20, Tween 20
Molecular Formula: C58H114O26
Applications: pharmaceutical, food additive, detergent, emulsifier, wetting age
Use: Polysorbate 20 is the essential ingredient for making body and room sprays. It acts as a solubiliser, allowing the oil phase of your formula to disperse and fully incorporate into the water phase. Polysorbate 20 is a solubilizer commonly used to bind fragrance and essential oils with water based products.
JECFA Food Additive:Polyoxyethylene (20) Sorbitan Monolaurate
GSFA Codex: Polyoxyethylene (20) sorbitan monolaurate (432)
DG SANTE Food Additives:polysorbate 20
Use: Our Polysorbate 20 (polyoxyethylene [20] sorbitan monolaurate) is derived from coconut oil. It is a non-toxic, nonionic surfactant/emulsifier and a water-soluble yellowish liquid used as a dispersing agent which allows oil and water to mix without the use of alcohol. It?s a fragrance solubilizer and stabilizer; it lubricates and has a soothing effect on the skin. This skin- safe ingredient is used extensively in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.) and also for body mists and linen sprays. Will be found as an ingredient in the majority of body toiletries, cosmetics and wipes now in the market. Polysorbates are generally used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for various purposes such as to disperse flavors and colors, to make essential oils and vitamins soluble and to improve volume and texture in baked goods. Use Polysorbate 20 when very little foaming action (or none at all) is desired in the finished product.
It is a highly hydrophilic surfactant and approved as a food additives. It is a usuful emulsifier, dispersant and solubilizer for aroma chemiclas and oils
Polysorbate 20 is a nonionic, solubilizer, o/w emulsifier, antistat and fiber lubricant used in textile industry, wetting agent, viscosity modifier, suspending agent used in food, cosmetics, drugs, textile and metal working industries, solubilizer for perfumes and flavours, insecticides, herbicides, paints and inks, pharmaceuticals.
Polysorbate 20 (common commercial brand names include Scattics, Alkest TW 20 and Tween 20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid.
Its stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
As the name implies the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.
Biotechnical applications
In biological techniques and sciences, polysorbate 20 has a broad range of applications.
Polysorbate 20 is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.
Industrial and domestic applications
Polysorbate 20 is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.
Polysorbate 20 is also used as wetting agent in rubber balers in the elastomer industry.
Polysorbate 20 has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies
Sorbitan monolaurate, ethoxylated
POLYSORBATE 20 is classified as :
Emulsifying
Surfactant
CAS Number 9005-64-5
COSING REF No: 79318
Chem/IUPAC Name: Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs.
Polysorbate 20 is a nonionic surfactant and emulsifing agent formed by the ethoxylation of sorbitan before the addition of lauric acid, and is often used in foods and personal care products.
Polysorbate 20 is a viscous, water-soluble yellow liquid.
The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case the oleic acid.
Polysorbate 20 is often used in cosmetic products as an emulsifier. Soluble in water & alcohols, it is insoluble in oils.
It’s a fragrance solubilizer and stabilizer; it lubricates and has a soothing effect on the skin.
This skin-safe ingredient is used extensively in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.) and also for body mists and linen sprays.
Polysorbate 20 functions to disperse oil in water rather than water in oil
INCI: Polysorbate 20
Specifications
Color: Yellow Liquid
Solubility: Soluble in water, methanol
Flashpoint:>298.4°F
Detergents Non ionic Detergents TWEEN 20
TWEEN 20
Tween 20 is a polyoxyethylene sorbitol ester containing approximately 20 units of ethylene oxide per unit of sorbitol.
The fatty acid composition is heterogeneous with lauric acid as major component (40 – 60 %).
Tween 20 is of importance in immunological determination procedures. It effectively suppresses unspecific reactions between antibodies, antigens, and other molecules.
Tween 20 can also be used as a solubilizer in membrane chemistry and as an additive for cell culture media.
In thiophilic interaction chromatography, Tween 20 has proved effective in the elution of strongly adsorbed proteins
Other notable applications are e.g. turbidimetric determination of lipolytic enzymes and density gradient centrifugation of viruses.
Synonyms: Polysorbate 20, Montanox 20, PEG (20) sorbitan monolaureate
CAS registry number: [9005-64-5]
Relative molecular mass (Mr): ca. 1200
Classification: Non-ionic surfactant
Literature specifications:
Critical micellar concentration (CMC): 0.059 mM
Cloud point (cp): 76 °C (3% in 1 N NaCl solution)
Partial specific volume: 0.869 cm3/g
Hydrophilic-lipophilic balance (HLB): 16.7
Tween 20 is a non-ionic surfactant often used to lower the surface tension of aqueous explant disinfectant solutions, Polysorbate 20, Polyoxyethlenesorbitan Monolaurate 20,
Polysorbate 20 is an ethoxylated sorbitan ester based on a natural fatty acid (lauric acid).
This ethoxylate is highly effective at forming oil in water emulsions, particularly when used in combination with its non-ethoxylated precursor, Sorbitan Monolaurate.
What is Polysorbate 20?
In its original form, polysorbate is a harmless sorbitol, which is a sugar alcohol. For its use in personal care products, however, it’s treated with ethylene oxide.
Thus, the name “polysorbate 20,” because it’s treated with 20 parts of ethylene oxide.
The result is an ingredient used as an emulsifier in cosmetic creams, lotions, cream deodorant, baby oil, sun lotion, etc. It is used to help mix oil and water.
Polysorbate 20
Tween 20
9005-64-5
Polyoxyethylene (20) sorbitan monolaurate
POLYOXYETHYLENE SORBITAN MONOLAURATE
Polysorbate (INN)
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate
2-(2-(3,4-Bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl dodecanoate
2-[2-[3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
9005-66-7
Alkest TW 20
Polysorbate 20
Polysorbate 40
Polysorbate 60
Tween 20
Tween 40
Tween 60
POE (6) sorbitol monolaurate
POE(20) sorbitan monolaurate
Ethoxylated Sorbitan monolaurate
POE (20) sorbitan monolaurate
Polyoxyethylenesorbitan monolaurate
PEG-3 SORBITAN STEA- RATE
E432
Polyoxyethylene Sorbitan Monolaurate Kosher
Polyoxyethylene Sorbitan Monolaurate 20 NF
C12 sorbitan monoester, 20 EO (polysorbate 20)
3,6-Anhydro-1-O-[2-(dodecanoyloxy)ethyl]-2,4,5-tris-O-(2-hydroxyethyl)hexitol
1052273-76-3
118955-40-1
Polysorbates are stable to electrolytes and weak acids and bases; gradual saponification occurs with strong acids and bases.
The oleic esters are sensitive to oxidation. Polysorbates are hygroscopic and should be examined for water content prior to use and dried if necessary.
Also, in common with other polyoxyethylene surfactants, prolonged storage can lead to the formation of peroxides.
Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.
Being derived mainly from natural materials, many of these versatile surfactants are water-soluble products that are used as emulsifiers, solubilizers, wetting agents, and dispersants throughout the food, cosmetics, and personal care industries.
These surfactants consist primarily of partial fatty acid esters (oleate, stearate or laurate) of sorbitol-derived cyclic ethers (sorbitans and sorbides) polymerized with approximately 20 molecules of ethylene oxide per molecule of polysorbate.
Polysorbate 20 is a lauric acid with an approximate hydrophilic-lipophilic balance of 16.7.
This product can be used as a solubilizing agent in oil-in-water emulsifications as well as a humectant in skin care products.
In addition, polysorbate-20 is frequently used as an indirect additive for food emulsification.
The Food and Drug Administration (FDA) allows polysorbates to be directly added to food as adjuvants and emulsifiers for flavoring agents
Synonyms:
alkamuls PSML-20
cremophor PS 20
emasol L-120V
glycosperse L-20 KFG
hetsorb L-20
kaopan TW-L-120
liposorb L-20
lonzest SML-20
monebatt – 20
mulsifan SML-20
nikkol TL-10
norfox sorbo T-20
peg-20 sorbitan laurate
peg-20 sorbitan monolaurate
polyethylene glycol (20) sorbitan laurate
polyethylene glycol (20) sorbitan monolaurate
polyoxyethylene (20) sorbitan laurate
polyoxyethylene (20) sorbitan monolaurate
rheodol TW-L120
super refined polysorbate 20
T-maz 20K
tween 20
Polysorbate 20
Tween 20
9005-64-5
POLYOXYETHYLENE SORBITAN MONOLAURATE
Polyoxyethylene (20) sorbitan monolaurate
Polyoxyethylenesorbitan monolaurate
Polysorbate (INN)
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate
2-(2-(3,4-Bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl dodecanoate
2-[2-[3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
9005-66-7
Alkest TW 20
Polysorbate 20 (NF)
Polysorbate 40 (NF)
Polysorbate 60 (NF)
Tween(R) 20
tween (R) 20
Tween 20 (TN)
Tween 40 (TN)
Tween 60 (TN)
SCHEMBL118527
POE (6) sorbitol monolaurate
POE(20) sorbitan monolaurate
CHEMBL371631
Ethoxylated Sorbitan monolaurate
POE (20) sorbitan monolaurate
DTXSID60922815
MFCD00165986
E432
Polyoxyethylene Sorbitan Monolaurate Kosher
FT-0645136
Polyoxyethylene Sorbitan Monolaurate 20 NF
C11624
D05565
D05566
D05567
3,6-Anhydro-1-O-[2-(dodecanoyloxy)ethyl]-2,4,5-tris-O-(2-hydroxyethyl)hexitol
1052273-76-3
118955-40-1
Product Description
CAS No: 9005-64-5
Appearance: Clear, yellow to yellow-green viscous
liquid
Boiling point: >100 °C
Brookfield Viscosity: 370-430 cps (25 °C, neat)
pH of 1% aqueous solution: 5-7
Refractive index: 1.46851
Specific gravity: 1.1
HLB (hydrophile-lipophile balance) value: 16.72
CMC value3: 60 mg/l
Structure: TWEEN 20 is a polyoxyethylene sorbitol ester, with a calculated molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, 1 sorbitol, and 1 lauric acid as the primary fatty acid.
Fatty acid constituents of this product are determined by transesterification to yield fatty acid methyl esters, which are identified by gas chromatography.
Synonyms: Polysorbate 20; PEG(20)sorbitan monolaurate, polyoxyethylenesorbitan monolaurate.
TWEEN 20 is a nonionic detergent widely used in biochemical applications.
TWEEN 20 is a frequently used member of the polysorbate family.
These have been used as emulsifying agents for the preparation of stable oil-in water emulsions.
TWEEN 20 has been used in preextraction of membranes to remove peripheral proteins (used at 2% for extraction of membranebound proteins).
Several resources may be helpful in determining usage concentrations.
TWEEN 20 has been used as a blocking agent for membrane based immunoassays at a typical concentration of 0.05%.
TWEEN 20 is suitable for use as a solubilizing agent of membrane proteins and as a blocking agent in Western blotting.
TWEEN 20 canbe used for lysing mammalian cells at a concentration of 0.05 to 0.5%.
Preparation Instructions
Polysorbate 20 is miscible in water (100 mg/ml), yielding a clear, yellow solution.
It is also miscible with alcohol,dioxane, and ethyl acetate; and is practically insoluble in liquid paraffin and fixed oils.
Storage/Stability
Aqueous solutions of polysorbates undergo autoxidation during storage, with changes being catalyzed by light, increased temperature, and copper sulfate.
Autoclaving is not recommended without testing for changes in properties.
TWEEN 20 may not be stable to autoclaving, particularly with metal cations in buffer solutions.
Polysorbate 20 is heat sensitive and will darken when exposed to elevated temperatures.
Polysorbates have been reported to be incompatible with alkalis, heavy metal salts, phenols, and tannic acid.
Polysorbates may reduce the activity of many preservatives.
No plastic incompatabilities have been observed.
Polysorbate 20 Chemical Properties,Uses,Production
Description
Tween 20, whose common commercial names includes Alkest TW 20 and Polysorbate 20, is a mild nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid which is a medium-chain fatty acid found mainly in coconut oil. It is allowed to be used as the emulsifier, detergent, dispersant, solvent and stabilizer, etc. in a number of fields such as pharmaceutical, chemical, food, textile and other industries due to its stability and relative non-toxicity.
Tween 20 is widely applied in biological techniques and sciences, which can be added to buffers and reagents for immunohistochemistry, such as Western blots and ELISAs, helping to prevent non-specific antibody binding, decrease background staining and enhance reagent spreading. Besides, Tween 20 also has applications in food production as a common food grade additive which are found in many consumables on the market today. It can also be used as a wetting agent in flavored mouth drops such as Ice Drops, in oral or non-gastrointestinal suspensions and in rubber balers in the elastomer industry.
References
https://en.wikipedia.org/wiki/Polysorbate_20
http://www.organic-creations.com/thickeners-stabilizers/599-polysorbate-20
Chemical Properties
Polysorbate 20 is a mixture of laurate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides.
It has a faint, characteristic odor and a warm, somewhat bitter taste.
Chemical Properties
Yellow liquid
Uses
Pharmaceutic aid (surfactant).
Uses
polysorbate 20 is a solubilizer, emulsifier, viscosity modifier, and stabilizer of essential oils in water.
Definition
ChEBI: A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a dodecanoyl group.
Preparation
By condensing the partial esters of sorbitol and its anhydrides with ethylene oxide to effect an oxyethylene copolymerization at the free hydroxyl groups.
brand name
Tween 20 (ICI Americas).
Safety Profile
Moderately toxic by intravenous route. Mddly toxic by ingestion. A human skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Polysorbate 20 Preparation Products And Raw materials
Raw materials
ETHYLENE OXIDE Sodium ethoxide
Polisorbate 20- PS 20
Tween 20 (Trademark of ICI America, Inc.)
Tween 20
Tween 20 1LT
Twain 20
TWEEN(R) 20 Vetec(TM) reagent grade, 40%
ACRYL/BIS 37.5:1 PREMIXED PWD ULTRA PURE
TWEEN 20 ELECTROPHORESIS GRADE
TWEEN 20 BP GRADE
Tween20(Polyoxyethylene-20-SorbitanMonolaurate)
Tween20=Polysorbate20
POLYSORBATE,20(BULK
POLYSORBATE,20,FCC
POLYSORBATE,20,NF
Polysorbate 20/80
POLYOXYETHYLENE(6)SORBITANMONOLAURATE
SORBITANPOLYOXYETHYLENEMONOLAURATE
POLYOXYETHYLENE(2)SORBITANMONOLAURATE
POLYOXETHYLENE(20)SORBITANMONOLAURATE
Sorbitan monolaureate, ethoxylated (4 EO)
Sorbitanmonolaurat, ethoxyliert, 20-EO
polyethylene glycol sorbitan monolaurate solution
polyoxyethylene (20)sorbitan monolaurate solution
polyoxyethylene (80) sorbitan monolaurate solution
Tween 20, Ph. Eur. & USP
ProteinSolubilizer20,ReadytouseAmpules,Sterile
Tween 20 (=Polyoxyethylene Sorbitan Monolaurate)
armotanpml-20
capmul
dxewmulsepoe-sml
emsorb6915
emulsifier(t20)
EmulsifierT-20
glycospersel-20
glycospersel-20x
hodagpsml-20
liposorbl-20
protasorbl-20
psml
sorbimacrogollaurate300
Sorbitan,monodadecanoate,poly(oxy-1,2-ethanediyl)derivs.
sorbitan,monododecanoate,poly(oxy-1,2-ethanediyl)derivs.
sorbitan,monododecanote,poly(oxy-1,2-ethanediyl)derivatives
POLYOXYETHYLENE SORBITAN MONOLAURATE*(TW EEN 20), PR
POLYOXYETHYLENE (20) SORBITAN MONOLAURATE SOLUTION, 72 WT.% IN WATER
POLYOXYETHYLENESORBITAN MONOLAURATE*CELL CULTURE TE
POLYOXYETHYLENESORBITAN MONOLAURATE*MOLE CULAR BIOLO
POLYOXYETHYLENE (20) SORBITAN MONOLAURATE SOLUTION, BIOCHEMIKA, ~10% WATER
TWEEN(R) 20 250-450 MPA.S
POLYOXYETHYLENESORBITAN MONOLAURATE*ELEC TROPHORESIS
POLYOXYETHYLENE SORBITAN MONOLAURATE*(TW EEN 20), LO
POLYSORBAT 20, PH EUR
TWEEN 20 EP, NF
TWEEN 20 CELL CULTURE REAGENT
TWEEN(-1)(R) 20
TWEEN 20
‘TWEEN’ 20
TWEEN 20(R)
Tween 20, whose common commercial names includes Alkest TW 20 and Polysorbate 20, is a mild nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid which is a medium-chain fatty acid found mainly in coconut oil. It is allowed to be used as the emulsifier, detergent, dispersant, solvent and stabilizer, etc. in a number of fields such as pharmaceutical, chemical, food, textile and other industries due to its stability and relative non-toxicity.
Tween 20 is widely applied in biological techniques and sciences, which can be added to buffers and reagents for immunohistochemistry, such as Western blots and ELISAs, helping to prevent non-specific antibody binding, decrease background staining and enhance reagent spreading. Besides, Tween 20 also has applications in food production as a common food grade additive which are found in many consumables on the market today. It can also be used as a wetting agent in flavored mouth drops such as Ice Drops, in oral or non-gastrointestinal suspensions and in rubber balers in the elastomer industry.
Polysorbate 20 is a mixture of laurate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides. It has a faint, characteristic odor and a warm, somewhat bitter taste.
Tween™ 20
Chemical Description
Polysorbate 20
Product Description
Tween 20 is an excellent O/W emulsifier, solubiliser and wetting agent.
Water-soluble emollient and barrier repair agent in cleansing products.
Tween 20 acts as a solubilising agent for oil soluble vitamins, essential oils and flavours in mouthwashes.
Effective wetting agent and dispersant for actives such as calamine, menthol and phenol. Recommended topical usage levels of 0.5-5%.
Is API stability a challenge ?
Try Tween 20 HP.
The Tween Series of surfactants are polyoxyethylene derivatives of the Span Series products.
Tween surfactants are hydrophilic, generally soluble or dispersible in water, and soluble in varying degrees of inorganic liquids.
They are widely used in personal care applications.
Sorbitol is a white, sweetish, hygroscopic, crystalline sugar alcohol of six-carbon. It is found naturally in various berries and fruits. Or it is prepared synthetically by high-pressure catalytic hydrogenation of glucose sugar derived from cornstarch. It melts at 93 to 98 C depending on the form. It is used as a a sweetening agent, food additive, toothpaste, tobacco, toiletries and in cosmetics. It is used for vitamin-C fermentation. It is used as a excipient and intravenous osmotic diuretic in pharmaceutical fields. It is also used in the manufacture of polyethers for polyurethanes and surfactants. The term sorbitan describes the anhydride form of sorbitol, whose fatty acids are lipophilic whereas sorbitol body is hydrophilic. This bifunctionality in one molecule provides the basic properties useful in cleaners, detergents, polymer additives, and textile industry as emulsifiers, wetting agents, and viscosity modifiers. Sorbitan esters are rather lipophilic (or hydrophobic) surfactants exhibiting low HLB (Hydrophilic-Lipophilic Balance) values; having an affinity for, tending to combine with, or capable of dissolving in lipids (or water-insoluble). While, the ethoxylated sorbitan esters are hydrophilics exhibiting high HLB values; having an affinity for water; readily absorbing or dissolving in water. The type of fatty acid and the mole number of ethylene oxide provides diverse HLB values for proper applications.
HLB numbers describe following characterestics:
<10 : Lipid soluble (or water-insoluble)
>10 : Water Soluble
4-8 : Antifoaming
7-11 : Water-in-oil emulsion
12-16 : Oil-in-water emulsion
11-14 : Good Wetting
12-15 : Good detergency
16-20 : Stabilizing
Sorbitan Fatty Acid Esters
Polyoxyethylene sorbitan esters are synthesized by the addition, via polymerization, of ethylene oxide to sorbitan fatty acid esters.
These nonionic hydrophilic emulsifiers are very effective antistaling agents and, thus, are used in a wide variety of bakery products.
These emulsifiers are much more widely known as the polysorbates, e.g., polysorbate 20, 60, and 80.
Polysorbate 20, 60, and 80 utilize lauric, stearate, and oleate, respectively, for the fatty acid portion of the molecule.
Polysorbate 60 is a monostearate, whereas polysorbate 65 is a tristearate.
HLB values of sorbitan compounds are:
Surfactants
HLB Value
CAS RN
Sorbitan hexastearate ethoxylate EO 6 mole
3.0
Sorbitan isostearate
4.3
Sorbitan laurate
8.6
1338-39-2
Sorbitan monoisostearate ethoxylate EO 20 mole
15.0
66794-58-9
Sorbitan monolaurate ethoxylate EO 20 mole
16.9
9005-64-5
Sorbitan monooleate ethoxylate EO 20 mole
15.0
9005-65-6
Sorbitan monopalmitate ethoxylate EO 20 mole
15.6
9005-66-7
Sorbitan monostearate ethoxylate EO 20 mole
14.9
9005-67-8
Sorbitan monostearate ethoxylate EO 6 mole
9.5
Sorbitan oleate
4.3
1338-43-8
Sorbitan palmitate
6.7
26266-57-9
Sorbitan sesquioleate
4.5
8007-43-0
Sorbitan stearate
4.7
1338-41-6
Sorbitan tetraoleate ethoxylate EO 30 mole
11.5
Sorbitan tetraoleate ethoxylate EO 40 mole
12.5
Sorbitan tetraoleate ethoxylate EO 6 mole
8.5
63089-86-1
Sorbitan tetrastearate ethoxylate EO 60 mole
13.0
66828-20-4
Sorbitan trioleate ethoxylate EO 20 mole
11.0
9005-70-3
Sorbitan trioleate
1.8
26266-58-0
Sorbitan tristearate ethoxylate EO 20 mole
10.5
9005-71-4
Sorbitan tristearate
2.1
26658-19-5
Polyoxyéthylène 20 Sorbitane mono-laurate
Polysorbate 20
Le polysorbate 20 est un agent nettoyant et solubilisant liquide destiné à être utilisé dans les soins capillaires, les articles de toilette, les parfums et les parfums.
Cette qualité est recommandée comme émulsifiant pour les systèmes H / E et comme solubilisant efficace pour les huiles essentielles et les parfums dans les systèmes aqueux et aqueux / alcooliques. Il est également utilisé comme additif de douceur dans les systèmes de détergent, par ex. shampoing et nettoyant pour bébé en lingettes humides.