DL-PANTOLACTONE
DL-PANTOLACTONE
DL-Pantolactone = 3-hydroxy-4,4-dimethyloxolan-2-one
CAS Number: 79-50-5
Molecular Formula: C6H10O3
Molecular Weight (g/mol): 130.14
EC Number: 209-963-3
Used in the synthesis of cosmetics and pharmaceuticals
Intermediate in the production of Calcium-D-pantothenate
DL-Pantolactone can be hydrolyzed to Pantoic acid by the lactonohydrolase of Fusarium oxysporum.
DL-Pantolactone has been widely used for the deracemization of 2-arylpropanoic acids through the intermediacy of a transient ketene.
With the related N-phenyl pantolactam 3a, the same process has been conducted with similar selectivities.
Additionally, the easily crystallizable and UV detectable chiral auxiliary can be efficiently recovered after saponification.
DL-Pantolactone also can be used in the preparation of 3,5-dinitrobenzoyl-DL-pantolactone
Spectrum Chemical manufactures and distributes fine chemicals with quality you can count on including those with CAS number 79-50-5, can be assured that all DL-Pantolactone products offered by Spectrum, meet or exceed the grade requirements or specifications for each individual product.
A chemical structure of DL-Pantolactone includes the arrangement of atoms and the chemical bonds that hold the atoms together.
The PANTOLACTONE molecule contains a total of 19 bond(s) There are 9 non-H bond(s), 1 multiple bond(s), 1 double bond(s), 1 five-membered ring(s), 1 ester(s) (aliphatic), 1 hydroxyl group(s) and 1 secondary alcohol(s).
Major Uses of DL-Pantolactone:
1, Typical applications
DL-Pantolactone Use as dispersing agent, emulsion stabilizer.
DL-Pantolactone Use as intermediates in organic synthesis.
2, Personal care products
Humectant, conditioning agent in personal care products.
Application
D-(-)-Pantolactone is a chiral auxiliary used in many asymmetric synthesis reactions.
DL-Pantolactone can be used as a chiral starting material to synthesize:
An insect sex pheromone named 1S,2S,3R-1-acetoxymethyl-2,3,4,4-tetrameth-ylcyclopentane.
(-)-Enantiomer of (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclopenta[e]isoindole-1,3(2H,6H)-dione, a norsesquiterpene alkaloid.
DL-Pantolactone bicyclic diterpene named isofregenedadiol.
DL-Pantolactone is an important intermediate for the production of pantothenic acid, panthenol, and calcium d-pantothenate.
DL-Pantolactone is an efficient method to obtain d-pantolactone by optical resolution of dl-pantolactone using d-lactonohydrolase.
In order to improve the hydrolysis rate of dl-pantolactone using immobilized d-lactonohydrolase which showed excellent pH and temperature stability, the process for optical resolution of dl-pantolactone using immobilized d-lactonohydrolase was investigated by optimization of hydrolysis condition.
The results showed that the optimum process for optical resolution of dl-pantolactone was: temperature 40°C, pH7.0, substrate concentration 20%, hydrolysis time 8 h.
Under the optimum condition, the hydrolysis rate of dl-pantolactone reached 36.8%, and the hydrolysis rate still remained at 85.6% of the original hydrolysis rate after 20 batches of reuse, indicating that immobilized d-lactonohydrolase had excellent operational stability.
Boiling Point: 246.0°C
Packaging: Glass bottle
Quantity: 25g
Flash Point: 122°C
Melting Point: 74.0°C to 78.0°C
Assay Percent Range: 96% min. (GC)
Solubility Information: Solubility in water: soluble.
Formula Weight: 130.14
Percent Purity: 97%
Chemical Name or Material: DL-Pantolactone
Not a skin sensitizer in guinea pig maximization test;
No reproductive or developmental toxicity observed in sub-chronic oral study of rats at doses up to 1,000 mg/kg/day (mild parental toxicity seen at this dose);
May cause irritation;
“Pantothenic acid.”
product Name DL-Pantolactone
Synonyms (+-)-dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one; 2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (+-)-; DL-alpha-Hydroxy-beta,beta-dimethyl-alpha-butyrolactone; DL-PANTOYL LACTONE; D-(-)-Pantoyl lactone
Molecular Formula C6H10O3
Molecular Weight 130.14
CAS Registry Number 79-50-5
EINECS 201-210-7
Derivative Type: D(-)-Form
Properties: Hygroscopic crystals from benzene + petr ether, mp 92°. [a]D25 -50.7° (c = 2.05 in H2O). Can be purified by microsublimation.
Melting point: mp 92°
Optical Rotation: [a]D25 -50.7° (c = 2.05 in H2O)
Derivative Type: L(+)-Form
Properties: Hygroscopic crystals from benzene, mp 91°. [a]D25 +50.1° (c = 2 in H2O).
Melting point: mp 91°
Optical Rotation: [a]D25 +50.1° (c = 2 in H2O)
Derivative Type: DL-Form
Properties: Hygroscopic rosettes or prisms, mp 80°, bp18 130°. Freely sol in water. Sol in ether, benzene, chloroform, alcohol, carbon disulfide.
Melting point: mp 80°
Boiling point: bp18 130°
Molecular Structure :
79-50-5 DL-泛酰内酯
Melting point 74-78℃
Physical Properties of DL-Pantolactone：
Appearance: White or light yellow crystalline different hydroxyl oxime acid iron reaction positive
Application:
DL-Pantolactone Used for pharmaceutical intermediates and cosmetics of raw materials.
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents — Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents — Determination of total arsenic
3, Further explanation
On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
DL-Pantolactone Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
DL-Lactone is used in the synthesis of cosmetics and pharmaceuticals.
DL-Pantolactone is an intermediate in the production of Calcium D-Pantothenates.
A small amount of DL-Pantolactone (0.17-0.53%) is isolated and sold to a third party.
DL-Pantolactone can be hydrolyzed to Pantoic acid by the lactonohydrolase of Fusarium oxysporum .
DL-Pantolactone also can be used in the preparation of 3,5-dinitrobenzoyl-DL-pantolactone
Melting point:74-78 °C (lit.)
Boiling point:121°C/11mmHg(lit.)
Density 1.165±0.06 g/cm3(Predicted)
Flash point:122℃
solubility H2O: soluble1g/10 mL, clear, colorless to almost colorless
pka13.12±0.40(Predicted)
BRN 80958
InChIKeySERHXTVXHNVDKA-UHFFFAOYSA-N
Product Identifier
DL-Pantolactone
The optical resolution of DL-pantolactone is effected by reacting DL-pantolactone or its alkali salt derived therefrom, respectively, with an optically active N-substituted aminophenylpropanol of the general formula:
##STR1## wherein R1 is a phenyl group which may be substituted and R2 is an aralkyl group in which the benzene ring may bear a substituent, or its mineral acid addition salt; separating the resulting diastereomers by the aid of difference in their dissolubility; and decomposing them to give the corresponding optical antipodes.
This method can provide the antipodes in high purity and yield and can be carried out with ease.
Hazard Category
Serious eye damage/eye irritation Category 2
Skin corrosion/irritation Category 2
Specific target organ toxicity Category 3
Hazard Statement
H319-Causes serious eye irritation.
H335-May cause respiratory irritation.
H315-Causes skin irritation.
Precautionary Statement
P280-Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352-IF ON SKIN: Wash with plenty of water/.
P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312-Call a POISON CENTER/doctor/if you feel unwell.
Product NameDL-Pantolactone
CAS79-50-5
SynonymsPantolactone;(1)-Dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one;2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-
CategoryHeterocyclic Organic Compound
Molecular Formula C6H10O3
Molecular Weight 130.14
Physical State Solid
A method of producing D-pantolactone from DL-pantolactone, which comprises asymmetrically hydrolyzing only the D-enantiomer of DL-pantolactone selectively with a microorganism as specified in the claim to give D-pantoic acid, and converting the separated D-pantoic acid into D-pantolactone.
Appearance：
White crystalline powder
Meltingpoint：
74~78℃
Description of DL-Pantolactone:
The present invention relates to the optical resolution of DL-pantolactone and, more particularly, to a method of optically resolving DL-pantolactone using an optically active N-substituted aminophenylpropanol.
The optically active antipode of DL-pantolactone or D-pantolactone is useful as an intermediate for preparing D-pantothenic acid which possesses a physiologically active property.
The L-pantolactone, on the other hand, is employed, after being racemized, as a starting material for racemic resolution and it is useful as an optically active resolving agent for dl-basic compounds.
Pantolactone which is obtainable by chemical synthesis is generally in the form of racemate so that its antipodes are obtained by the racemic resolution method.
Many attempts have heretofore been made to optically resolving DL-pantolactone using a variety of optically active resolving agents.
For example, there are disclosed quinine in U.S. Pat. No. 2,319,545; brucine in U.S. Pat. Nos. 2,474,719 and 3,009,922; ephedrine in U.S. Pat. Nos. 2,460,239 and 2,460,240 and Czechoslovak Pat. No. 88,066; 1-p-nitrophenyl-2-amino-1,3-propanediol in Pat. No. 37,505 of Democratic Republic of Germany and Japanese Patent Publication No. 9,176/1966; L-amino acids in Japanese Patent Publication No. 12,149/1968; dehydroabiethylamine in Canadian Patent No. 770,177; and d-alpha-threonamine in U.S.S.R. Pat. No. 201,426.
These known agents, however, cannot give a high optical yield and have disadvantages in industrial application and economy because they are expensive and their procedures are complicated.
DL-Pantolactone is therefore an object of the present invention to provide a method by which DL-pantolactone is optically resolved easily and efficiently on an industrial scale.
Other objects, advantages and features of the present invention will become apparent in the following description of the specification and from the appended claims.
The method of the present invention involves reacting DL-pantolactone or its alkali salt derived therefrom, respectively, with an optically active N-substituted aminophenylpropanol of the general formula:
##STR2## wherein R1 is a phenyl group which may be substituted and R2 is an aralkyl group in which the benzene ring may bear a substituent, or its mineral acid addition salt; separating the resulting diastereomers by the aid of difference in their dissolubility; and decomposing them to give the corresponding optical antipodes.
The phenyl group in the R1 group may be substituted by a halogen atom such as chlorine, an aliphatic lower alkyl group having from 1 to 4 carbon atoms such as methyl or ethyl and/or an aliphatic lower alkoxy group in which the alkyl group is the same as above.
The aralkyl group in the R2 group may be an aralkyl having from 7 to 10 carbon atoms such as benzyl, phenethyl, phenylpropyl or alpha-methylbenzyl in which the phenyl group may be substituted by a halogen atom such as chlorine, an aliphatic lower alkyl group such as methyl or ethyl and/or an aliphatic lower alkoxy group having the same alkyl group as above.
The optically active N-substituted aminophenylpropanol may also be employed in the form of an acid addition salt. For this purpose, the acid addition salt may be prepared in conventional manner using a mineral acid such as hydrochloric or sulfuric acid.
In the practice of the method according to the present invention, the diastereomers corresponding to the D- and L-pantolactone can be obtained in both cases where an alkali salt of DL-pantoic acid is treated with a mineral acid addition salt of an optically active N-substituted aminophenylpropanol and where DL-pantolactone is treated with free, optically active N-substituted aminophenylpropanol.
The alkali salt of DL-pantoic acid is obtainable by treating the DL-pantolactone with an alkali, such as alkali metal hydroxide, e.g., sodium or potassium hydroxide to split off its lactone ring and then neutralizing excess alkali with a mineral acid, such as hydrochloric or sulfuric acid.
Where d-N-substituted aminophenylpropanol or its mineral acid addition salt is employed as the resolving agent, D-pantoic acid d-N-substituted aminophenylpropanol salt is formed as the sparingly soluble diastereomer, and L-pantoic acid d-N-substituted aminophenylpropanol salt is produced as the easily soluble one.
Where l-N-substituted aminophenylpropanol or its mineral acid addition salt is used as the resolving agent, L-pantoic acid l-N-substituted -N-substituted aminophenylpropanol is the sparingly soluble diastereomer and D-pantoic acid l-N-substituted aminophenylpropanol salt is the easily soluble diastereomer.
Since the sparingly soluble diastereomer and the corresponding easily soluble one exhibit a difference in dissolubility between each other to a great extent, one diastereomer can be isolated as pure crystals from the other.
Accordingly, this procedure can avoid the recrystallization step which otherwise is needed for the complicated separation of the sparingly soluble diastereomer and can provide the sparingly soluble diastereomer with efficacy from an industrial point of view and in high yields and with high purity.
The amount of the optically active resolving agent can be reduced to about half mole stoichiometrically with respect to the compound to be optically resolved.
In this case, no formation of any undesired material is recognized.
A solvent in which the diastereomers are formed and from which they are separated is usually water or an aqueous solution containing an organic solvent such as an aliphatic lower alcohol, e.g., methanol, ethanol or isopropanol and/or an aliphatic lower ketone, e.g., acetone.
However, water is preferred from the economic standpoint.
The diastereomers obtained by said procedure may be easily decomposed with an alkali such as an alkali metal hydroxide, e.g., sodium or potassium hydroxide or a mineral acid such as hydrochloric acid or sulfuric acid. The sparingly soluble diastereomer is treated first with said alkali and then with a solvent incompatible with water such as benzene or ether.
The resulting aqueous phase is heated with a mineral acid such as hydrochloric or sulfuric acid and then extracted with an organic solvent such as chloroform or ether, thereby causing the formation of the optically active pantolactone.
The mother liquor from which the sparingly soluble diastereomer was separated is further treated with said alkali and then in substantially the same manner as described above to give the corresponding optically active pantolactone.
Where a mineral acid is employed, substantially the same procedures as with said alkali may be taken.
The method of the present invention has the advantages from the industrial point of view in that DL-pantolactone can be converted into its optical antipodes in high purity and yields, the recrystallization of sparingly soluble diastereomers which are otherwise very complicated is not needed and the optically active resolving agent to be used is not subject to denaturation and can be so recovered almost quantitatively that the optical resolution can be effected in a stable and continuous manner.
The following examples serve to illustrate the present invention but they should not be construed as limiting the same thereto.
In the following Examples, the optical rotation is expressed as [α]D.
EXAMPLE 1
A. A solution of 26.0 g. (0.2 mole) of DL-pantolactone in 50 ml. of water containing 8.2 g. of sodium hydroxide was adjusted to pH 7.2 with a 10% hydrochloric acid solution.
To this mixture was added a solution of 33.3 g. (0.12 mole) of d-N-benzylphenylpropanolamine hydrochloride in 200 ml. of water which had been heated on a water bath to dissolve the hydrochloride therein.
The resulting mixture was cooled, thereby precipitating out crystals which were then filtered and washed with water to give 38.4 g. (yield, 98.6%) of crystalline D-pantoic acid d-N-benzylphenylpropanolamine having an optical rotation of +17.8° in methanol.
A solution of 36.3 g. of said crystals in 45 ml. of a 10% sodium hydroxide aqueous solution was washed three times with 50 ml. of benzene.
To the aqueous layer was added 20 ml. of concentrated hydrochloric acid, and the mixture was heated for 30 minutes at 80° C. on a water bath.
The mixture was cooled and extracted continuously overnight with chloroform.
The chloroform layer was then dried over anhydrous sodium sulfate and the removal of the solvent gave 11.0 g. (yield, 89.5%) of D-pantolactone as crystals having an optical rotation in water of -49.8° and a melting point of 89° to 90° C.
b. The mother liquor from which D-pantoic acid d-N-benzylphenylpropanolamine had been separated was combined with said water washing, and the water was removed under reduced pressure therefrom.
The resulting residue was dissolved 55 ml. of a 10% sodium hydroxide aqueous solution and washed three times with 50 ml. of benzene. The aqueous layer was mixed with 30 ml. of concentrated hydrochloric acid and heated for 30 minutes at 80° C. on a water bath. After the mixture was cooled, it was extracted with chloroform continuously overnight.
The organic phase was dried over anhydrous sodium sulfate and the removal of the solvent therefrom left the residue which was in turn recrystallized from a trichlene-ligroin mixture, thereby giving 11.4 g. (yield, 87.8%) of L-pantolactone as crystals having an optical rotation in water of +50.0° and a melting point of 89° to 90° C.
c. All of said benzene phases were combined and, after the removal of the solvent and the adjustment to pH 5.2 with a 5% hydrochloric acid solution, the water was distilled off under reduced pressure to give 33.2 g. (recovery, 99.7%) of d-N-benzylphenylpropanolamine hydrochloride having an optical rotation in methanol of +10.6° and a melting point of 201° C.
EXAMPLE 2
a. The procedure of Example 1 was repeated except for using 33.3 g. of l-N-benzylphenylpropanolamine hydrochloride, thereby giving 38.4 g. (yield, 98.6%) of L-pantoic acid l-N-benzylphenylpropanolamine -N-benzylphenylpropanolamine as crystals having an optical rotation of -17.8° in methanol.
With 36.3 g. of said crystals and the procedure of Example 1(a) above, L-pantolactone was produced with yield of 10.9 g. (88.7%) as crystals having an optical rotation in water of +49.3° and a melting point of 89° to 90° C.
b. With the procedure of Example 1(b) above, the mother liquor from which the L-pantoic acid l-N-benzylphenylamine had been separated was treated to give 11.3 g. (yield, 86.9%) of D-pantolactone having an optical rotation in water of -49.7° and a melting point of 89° to 90° C.
c. By following the procedure of Example 1(c), said benzene phases gave 33.3 g. (recovery, 100%) of l-N-benzylphenylpropanolamine 1-N-benzylphenylpropanolamine hydrochloride having an optical rotation in methanol of -10.6° and a melting point of 201° C.
EXAMPLE 3
a. A mixture of 26.0 g. (0.2 mole) of DL-pantolactone, 28.9 g. (0.12 mole) of d-N-benzylphenylpropanolamine and 250 ml. of water was heated for 2 hours on a boiling water bath while being stirred and cooled to form a precipitate which was in turn filtered and washed with water.
This gave 37.6 g. (yield, 96.5%) of D-pantoic acid d-N-benzylphenylpropanolamine as crystals having an optical rotation of +17.8° in methanol.
A solution of 35.3 g. of said crystals in 45 ml. of a 10% sodium hydroxide aqueous solution was washed three times with 50 ml. of benzene. After the addition of 20 ml. of concentrated hydrochloric acid to the aqueous layer, the mixture was heated for 30 minutes at 80° C. on a water bath.
The cooled mixture was then extracted with chloroform continuously overnight and the chloroform phase was dried over anhydrous sodium sulfate. The removal of the chloroform therefrom gave 10.7 g. (yield, 87.7%) of D-pantolactone as crystals which had an optical rotation in water of -49.7° and a melting point of 89° to 90° C.
b. The mother liquor from which said crystals had been separated and said water washing were combined and treated under reduced pressure to distil off the water. The resulting residue was dissolved in 55 ml. of a 10% sodium hydroxide aqueous solution and washed three times with 50 ml. of benzene.
The aqueous layer was then mixed with 30 ml. of concentrated hydrochloric acid and heated for 30 minutes at 80° C. on a water bath. After being cooled, the mixture was extracted with chloroform continuously overnight. The chloroform phase was dried over anhydrous sodium sulfate, and the removal of the chloroform and recrystallization from a benzene-ligroin mixture gave 11.1 g. (yield, 85.4%) of L-pantolactone as crystals having an optical rotation in water of +50.1° and a melting point of 89° to 90° C.
EXAMPLE 4
a. A solution of 26.0 g. (0.2 mole) of DL-pantolactone in 50 ml. of an aqueous solution containing 11.5 g. of potassium hydroxide was mixed with a solution which was obtained by adding 49.2 g. (0.16 mole) of d-N-p-methoxybenzylphenylpropanolamine hydrochloride to 200 ml. of water which was previously adjusted to pH 7.2 with a 10% hydrochloric acid solution and then by heating the mixture on a water bath to dissolve the hydrochloride in water.
After being cooled, the mixture was filtered to collect the crystalline material which was in turn washed with water to give 41.8 g. (yield, 99.7%) of D-pantoic acid d-N-p-methoxybenzylphenylpropanolamine as crystals having an optical rotation of +10.8° in methanol.
A solution of 39.5 g. of said crystals in 55 ml. of a 10% potassium hydroxide aqueous solution was washed three times with 80 ml. of ether.
The aqueous layer was mixed with 20 ml. of concentrated hydrochloric acid and heated for 30 minutes at 80° C. on a water bath. After being cooled, the mixture was extracted with chloroform continuously overnight and the chloroform phase was dried over anhydrous sodium sulfate.
The removal of the solvent from said chloroform phase gave 11.0 g. (yield, 89.5%) of D-pantolactone having an optical rotation in water of -49.8° and a melting point of 89° to 90° C.
b. The liquid from which said amine salt of D-pantoic acid had been separated and said water washing were combined.
The water was removed from the combined solution under reduced pressure, leaving the residue to which 65 ml. of a 10% potassium hydroxide aqueous solution was added. After being washed three times with 80 ml. of ether, the aqueous phase was mixed with 30 ml. of concentrated hydrochloric acid and heated for 30 minutes at 80° C.
After being cooled, the resulting solution was then extracted with chloroform continuously overnight and the extract was dried over anhydrous sodium sulfate.
The chloroform was distilled off and the residue was recrystallized from a benzene-ligroin mixture to give 11.3 g. (yield, 86.9%) of L-pantolactone as crystals which had an optical rotation in water of +50.0° and a melting point of 89° to 90° C.
c. All of said ether phases were combined and treated to distil off the solvent.
After the residue was adjusted to pH 5.2 with a 5% hydrochloric acid solution, the solution was concentrated to dryness under reduced pressure, thereby giving 48.8 g. (recovery, 99.2%) of d-N-p-methoxybenzylphenylpropanolamine hydrochloride having an optical rotation in methanol of +3.3° and a melting point of 186° C.
EXAMPLE 5
a. A mixture of 26.0 g. (0.2 mole) of DL-pantolactone, 43.4 g (0.16 mole) of l-N-p-methoxybenzylphenylpropanolamine and 300 ml. of water was stirred for 2 hours on a boiling water bath.
After being cooled, the reaction mixture was filtered to collect the formed crystals which were in turn washed with water, thereby giving 40.5 g. (yield, 96.6%) of L-pantoic acid l-N-p-methoxybenzylphenylpropanolamine as crystals having an optical rotation of -10.8° in methanol.
A solution of 38.5 g. of said cyrstals in 55 ml. of a 10% potassium hydroxide aqueous solution was washed three times with 80 ml. of ether.
To the aqueous layer was added 15 ml. of a 50% sulfuric acid solution, and the mixture was heated for 30 minutes at 80° C. on a water bath.
After being cooled, the mixture was extracted with chloroform continuously overnight and the extract was dried over anhydrous sodium sulfate.
The removal therefrom of the solvent gave 10.8 g. (yield, 87.4%) of L-pantolactone as crystals having an optical rotation in water of +49.9° and a melting point of 89° to 90° C.
b. The mother liquid from which said amine salt of L-pantoic acid had been separated was combined with said water washing, and the water was distilled off from said combined mixture under reduced pressure. The resulting residue was dissolved in 65 ml. of a 10% potassium hydroxide aqueous solution, and the resulting solution was washed three times with 80 ml. of ether.
The aqueous layer was mixed with 18 ml. of a 50% sulfuric acid solution and the mixture was heated for 30 minutes at 80° C. on a water bath.
After being cooled, the mixture was extracted with chloroform continuously overnight and the extract was dried over anhydrous sodium sulfate. The removal of the solvent therefrom and the subsequent recrystallization thereof from a benzene-ligroin mixture gave 11.1 g. (yield, 85.4%) of D-pantolactone as crystals having an optical rotation in water of -50.1° and a melting point of 89° to 90° C.
EXAMPLE 6
a. A solution of 26.0 g. (0.2 mole) of DL-pantolactone in 50 ml. of an aqueous solution containing 8.2 g. of sodium hydroxide was adjusted to pH 7.2 with 10% hydrochloric acid.
To this solution was added a solution which was previously obtained by adding 62.5 g. (0.2 mole) of l-N-o-chlorobenzylphenylpropanolamine -N-o-chlorobenzylphenylpropanolamine hydrochloride to 300 ml. of water and heating the mixture on a water bath to dissolve the hydrochloride in water.
After being cooled, the mixture was filtered to collect the formed crystals which were in turn washed with water to give 37.7 g. (yield, 89.0%) of L-pantoic acid l-N-o-chlorobenzylphenyllpropanolamine as crystals having an optical rotation of -16.7° in methanol.
A solution of 35.0 g. of said crystals in 45 ml. of a 10% sodium hydroxide aqueous solution was washed three times with 50 ml. of benzene.
The aqueous phase was mixed with 15 ml. of 50% sulfuric acid and heated for 30 minutes at 80° C. on a water bath.
After being cooled, the mixture was extracted with chloroform continuously overnight, followed by the drying over anhydrous sodium sulfate and the removal of the chloroform. This gave 9.8 g. (yield, 81.2%) of L-pantolactone as crystals having an optical rotation in water of +49.9° and a melting point of 89° to 90° C.
b. The mother liquor from which said amine salt of L-pantoic acid had been removed and said water washing were combined, and the water was distilled off from the mixture under reduced pressure.
The resulting residue was dissolved in 55 ml. of a 10% sodium hydroxide aqueous solution, and the mixture was washed three times with 50 ml. of benzene.
To this aqueous layer was added 18 ml. of 50% sulfuric acid, and the mixture was heated for 30 minutes at 80° C. on a water bath, followed by cooling said mixture and extracting it with chloroform continuously overnight.
After the extract was dried over anhydrous sodium sulfate, the chloroform was removed and the residue was recrystallized from a mixture of 1,2-dichloropropane and petroleum benzene to give 10.6 g. (yield, 81.5%) of crystalline D-pantolactone having an optical rotation of -50.1° in water and a melting point of 90° to 91° C.
c. A combined mixture of all said benzene phases was treated in the same manner as in Example 4(c) to give 62.0 g. (recovery, 99.2%) of l-N-o-chlorobenzylphenylpropanolamine hydrochloride having an optical rotation in methanol of -15.2° and a melting point of 195° C.
EXAMPLE 7
a. A solution of 26.0 g. (0.2 mole) of DL-pantolactone in 50 ml. of an aqueous solution containing 8.2 g. of sodium hydroxide was adjusted to pH 7.2 with 10% hydrochloric acid.
To this solution was added a solution which had been obtained by adding 35.0 g. (0.12 mole) of d-N-p-methylbenzylphenylpropanolamine hydrochloride to 60 ml. of methanol while being heated on a water bath.
The resulting mixture was left to stand overnight to precipitate out crystals.
The crystals were filtered and washed with a 50% methanol solution, thereby giving 36.1 g. (yield, 89.5%) of D-pantoic acid d-N-p-methylbenzylphenylpropanolamine as crystals having an optical rotation of +11.7° in methanol.
A solution of 33.0 g. of said crystals in 45 ml. of a 10% sodium hydroxide aqueous solution was washed three times with 50 ml. of benzene.
This aqueous layer was mixed with 20 ml. of concentrated hydrochloric acid and heated for 30 minutes at 80° C. on a water bath. After being cooled, the solution was extracted continuously with chloroform overnight and the chloroform phase was dried over anhydrous sodium sulfate to be followed by distilling off the solvent therefrom, thereby giving 10.0 g. (yield, 84.1%) of D-pantolactone as crystals having an optical rotation of -48.4° in water and a melting point of 88° to 89° C.
b. A combined mixture of the mother liquor from which said amine salt of D-pantoic acid had been separated and said water washing was treated under reduced pressure to distil off the solvent.
The resulting residue was dissolved in 55 ml. of a 10% sodium hydroxide aqueous solution and washed three times with 50 ml. of benzene. The aqueous layer was mixed with 30 ml. of concentrated hydrochloric acid to be followed by heating the mixture for 30 minutes at 80° C. on a water bath and cooling it.
The resulting solution was then extracted with chloroform continuously overnight, followed by the drying of the organic layer over anhydrous sodium sulfate and removing the solvent therefrom.
The resulting residue was then recrystallized from trichlene to give 10.2 g. (yield, 78.5%) of L-pantolactone as crystals which had an optical rotation in water of +47.9° and a melting point of 88° to 89° C.
EXAMPLE 8
a. A solution of 26.0 g. (0.2 mole) of DL-pantolactone in 50 ml. of an aqueous solution containing 8.2 g. of sodium hydroxide was adjusted to pH 7.2 with 10% hydrochloric acid.
To this solution was added a solution of 61.2 g. (0.2 mole) of l-N-(gamma-phenylpropyl)phenylpropanolamine hydrochloride which had been dissolved in 100 ml. of methanol by heating the mixture on a water bath.
After the removal of the solvent from said mixture and the addition thereto of isopropyl alcohol, the precipitated sodium chloride was filtered off and the filtrate was left to stand overnight.
The mixture was then filtered and washed with isopropyl alcohol to give 31.3 g. (yield, 75.0%) of L-pantoic acid l-N-(gamma-phenylpropyl)phenylpropanolamine as crystals.
They had an optical rotation of +19.9° in methanol.
A solution of 29.0 g. of said crystals in 45 ml. of a 10% sodium hydroxide aqueous solution was washed three times with 50 ml. of benzene.
The aqueous layer was mixed with 20 ml. of concentrated hydrochloric acid and heated for 30 minutes at 80° C. on a water bath, followed by cooling the mixture and then extracting it with chloroform continuously overnight.
The chloroform layer was then dried over anhydrous sodium sulfate, and the chloroform was removed to give 8.5 g. (yield, 70.6%) of crystalline L-pantolactone having an optical rotation in water of +48.5° and a melting pont of 88° to 89° C.
The 2D chemical structure image of DL-Pantolactone is also called skeletal formula, which is the standard notation for organic molecules.
The carbon atoms in the chemical structure of DL-Pantolactone are implied to be located at the corner(s) and hydrogen atoms attached to carbon atoms are not indicated – each carbon atom is considered to be associated with enough hydrogen atoms to provide the carbon atom with four bonds.
The 3D chemical structure image of DL-Pantolactone is based on the ball-and-stick model which displays both the three-dimensional position of the atoms and the bonds between them.
The radius of the spheres is therefore smaller than the rod lengths in order to provide a clearer view of the atoms and bonds throughout the chemical structure model of PANTOLACTONE.
DL-Pantolactone
79-50-5
3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one
PANTOLACTONE
pantoyl lactone
DL-Pantoyl Lactone
3-hydroxy-4,4-dimethyloxolan-2-one
2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-
52126-90-6
DL-Pantolactone, 97%
Pantolyl lactone
2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (R)-
(D)-Pantolactone
D-(-)-Pantolyl lactone
D-(-)-Pantoic acid lactone
D,L-Pantolactone
alpha-hydroxy-beta
D(-)Pantolactone
Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone
EINECS 201-210-7
MFCD00064333
AI3-23741
A-HYDROXY-,-DIMETHYL-G-BUTYROLACTONE
alpha-Hydroxy-beta,beta-dimethyl-gamma-butyrolactone
D(-)-2-Hydroxy-3,3-dimethyl-.gamma.-butyrolactone
DL-2-Hydroxy-3,3-dimethyl-gamma-butyrolactone
EC 201-210-7
2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, D-(-)-
3-Hydroxy-4,4-dimethyldihydro-2(3H)-furanone-, D-(-)- #
SCHEMBL152955
D-(-)-.alpha.Hydroxy-.beta.,.beta.-dimethyl-.gamma.-butyrolactone
(+-)-dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one
CHEMBL4066633
DTXSID40861637
NSC5926
NSC8113
NSC8114
AMY22249
NSC-5926
NSC-8113
NSC-8114
BBL005601
NSC135788
STK801814
AKOS003624024
Pro-vitamin B5, D-(-)-Pantolactone
MCULE-2206761895
NSC-135788
AK114317
AK140668
AS-12830
SY040562
SY110580
2-hydroxy-3,3-dimethyl-gamma-butyrolactone
DB-053494
DB-056366
A8842
CS-0046126
FT-0624340
FT-0625501
FT-0635675
H-imidazo[1,2-a]pyridine-2-carboxylic acid
P0010
T8187
4,4-Dimethyl-3-hydroxy-dihydro-2(3H)-furanone
DL-|A-Hydroxy-|A,|A-dimethyl-|A-butyrolactone
120708-EP2298729A1
SR-01000944792
SR-01000944792-1
W-104261
(1)-Dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one
Q22829045
(+/-)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone
2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, ( )-
DL-alpha-Hydroxy-beta,beta-dimethyl-gamma-butyrolactone, 97%
2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (.+/-.)-
3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one (DL-Pantolactone)
DL-alpha-Hydroxy-beta,beta-dimethyl-gamma-butyrolactone, purum, >=98.0% (T)
Solubility soluble in water.
Stability stable.
Under strong alkali condition, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system.
Harmful products of combustion are CO, CO2 and so on.
Contact with strong oxidants, can cause to burn.
introducing isobutyraldehyde, formalin and sodium cyanide solution continuously at a predetermined rate into a circulation reactor, continuously circulating the said mixture in said reactor while cooling the circulating mass in a heat exchanger, thus continuously causing the heat generated in the reaction between the components of said mixture to be discharged in said heat exchanger and by continuously re-mixing the formed reaction product with the reaction components;
continuously passing part of the reaction product into an after-treatment reactor where the said reaction is completed without re-mixing so as to form formisobutyraldolcyanohydrin;
passing the latter product into a first reaction chamber, reacting therein the product with a continuously introduced non-oxidizing strong acid at an elevated temperature and pressure so as to hydrolyze the product, thus forming a solution of α,γ-dihydroxy-β,β-dimethylbutyric acid;
passing the said solution to a second reaction chamber and maintaining the solution therein at said elevated temperature and pressure until the α,γ-dihydroxy-β,β-dimethylbutyric acid is lactonized to DL-α-hydroxy-β,β-dimethyl-γ-butyrolactone and finally recovering the latter product from the acid solution.
The process permits obtaining DL-pantolactone in a continuous operation at a high yield.
Item
DL-Pantolactone
CAS Number
79-50-5
Molecular Weight
130.14
Chemical Formula
C6H10O3
Chemical Container Material
Clear Glass
Chemical Container Type
Bottle
Chemical Grade
Reagent
Chemical Container Size
25 g
Chemical Family Type
Analytical Reagents
Shelf Life
24 mo
Synonyms
Ai3-23741;
DL-LACTONE;
PANTOLACTONE;
de-Pantolactone;
DL-PantolaCLone;
DL-PANTOLACTONE;
Einecs 201-210-7;
PANTOLACTONE(DL-);
DL-R-BUTYROLACTONE;
DL-γ-butyrolactone
DL-Pantolactone
(±)-pantolactone
Pantolactone
2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl- [ACD/Index Name]
2,4-Dihydroxy-3,3-dimethylbutyric acid γ-lactone
209-963-3 [EINECS]
3-Hydroxy-4,4-dimethyldihydro-2(3H)-furanon [German] [ACD/IUPAC Name]
3-Hydroxy-4,4-dimethyldihydro-2(3H)-furanone [ACD/IUPAC Name]
3-Hydroxy-4,4-diméthyldihydro-2(3H)-furanone [French] [ACD/IUPAC Name]
3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one
599-04-2 [RN]
Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone
Dihydro-3-hydroxy-4H-dimethyl-2(3H)-furanone
DL-Pantoic acid γ-lactone
Pantoic Acid g-Lactone
Pantoic lactone
Pantolactone
PANTOLACTONE, (±)-
PANTOLACTONE, (R)-
Pantothenic lactone
Pantoyl lactone
α-Hydroxy-β,β-dimethyl-γ-butyrolactone
β,β-Dimethyl-α-hydroxy-γ-butyrolactone
(±)-dihydro-3-hydroxy-4,4-dimethyl-2(3h)-furanone
(±)-Pantoyl lactone
(2S)-N,N-Dimethylpyrrolidine-2-carboxamide
(3R)-3-hydroxy-4,4-dimethyl-2-oxolanone
(3R)-3-hydroxy-4,4-dimethyloxolan-2-one
(±)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone
(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one
(S)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one
[5-(6-amino-2-fluoro-9-purinyl)-3,4-dihydroxy-2-oxolanyl]methyl dihydrogen phosphate
[79-50-5]
2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (±)-
2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (±)-
2,4-Dihydroxy-3,3-dimethylbutanoic acid γ-lactone
3-Hydroxy-4,4-dimethyl-dihydro-furan-2-one
3-hydroxy-4,4-dimethyloxolan-2-one
3-hydroxy-4,4-dimethyl-tetrahydrofuran-2-one
A-HYDROXY-,-DIMETHYL-G-BUTYROLACTONE
D,L-Pantolactone
dl-2-hydroxy-3,3-dimethyl-4-butanolide
DL-Pantoyl lactone
DL-α-Hydroxy-β,β-dimethyl-γ-butyrolactone
D-Pantoyl lactone
H-Pro-NMe2
MFCD00005392 [MDL number]
Z-DL-Phg-NHCyh