Venlafaxine Hydrochloride / Venlafaxine HCl CAS: 99300-78-4

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Name: Nicorandil

CASNO:65141-46-0

Purity:97% min

MF:C8H9N3O4

MW:211.175

BP:456.7±25.0 °C at 760 mmHg

Density:1.3±0.1 g/cm3

MP:92ºC

EINECS:N/A

Appearance:white or off-white powder

Package:25g, 100g, 500g, bulk package

Application:Pharmaceutical intermediate

Storage Condition: Desiccate at +4ºC

Othername:

2-(pyridine-3-carbonylamino)ethyl nitrate;

Ikorel;

SG-75;

Dancor;

Nikoran;

Nicorandilum;

N-(2-hydroxyethyl)nicotinamide nitrate ester;

Adancor;

N-[2-(nitroxy)ethyl]-3-pyridine carboxamide;

2-Nicotinamidoethyl nitrate;

Nicorandil CAS NO: 65141-46-0 is a vasodilatory drug used to treat angina. It is marketed under the trade names Ikorel (in the United Kingdom, Australia and most of Europe), Angedil (in Romania, Poland), Dancor (in Switzerland), Nikoran,PCA (in India), Aprior (in the Philippines), Nitorubin (in Japan), and Sigmart (in Japan, South Korea and Taiwan). Nicorandil CAS NO: 65141-46-0 is not available in the United States.

Angina is chest pain that results from episodes of transient myocardial ischemia. This can be caused by diseases such as atherosclerosis, coronary artery disease and aortic stenosis. Angina commonly arises from vasospasm of the coronary arteries. There are multiple mechanisms causing the increased smooth muscle contraction involved in coronary vasospasm, including increased Rho-kinase activity. Increased levels of Rho-kinase inhibit myosin phosphatase activity, leading to increased calcium sensitivity and hypercontraction. Rho-kinase also decreases nitric oxide synthase activity, which reduces nitric oxide concentrations. Lower levels of nitric oxide are present in spastic coronary arteries. L-type calcium channel expression increases in spastic vascular smooth muscle cells, which could result in excessive calcium influx, and hypercontraction.

Nicorandil CAS NO: 65141-46-0 is an anti-angina medication that has the dual properties of a nitrate and K+ATP channel agonist. In humans, the nitrate action of nicorandil dilates the large coronary arteries at low plasma concentrations. At high plasma concentrations nicorandil CAS NO: 65141-46-0 reduces coronary vascular resistance, which is associated with increased K+ATP channel opening.